Tissue Transglutaminase (tTG), IgG

CPT: 86364
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Expected Turnaround Time

2 - 3 days


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Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Specimen should be free of bacterial contamination, hemolysis, and lipemia.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination


Test Details


Use

Detection of antibodies to aid in the diagnosis of gluten-sensitive enteropathy (GSE), such as celiac disease and dermatitis herpetiformis


Limitations

A negative result does not rule out celiac disease. The inclusion of the tTG IgG autoantibodies is important because it is not uncommon for celiac patients to be IgA deficient. Results of this assay should be used in conjunction with clinical findings and other serological tests.


Methodology

Enzyme immunoassay (EIA)


Reference Interval

• Negative: <6 units/mL

• Weak positive: 6−9 units/mL

• Positive: >9 units/mL


References

Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul; 3(7):797-801. 9212111
Volta U, Molinaro N, De Franchis R, et al. Correlation between IgA antiendomysial antibodies and subtotal villous atrophy in dermatitis herpetiformis. J Clin Gastroenterol. 1992 Jun; 14(4):298-301. 1607605

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164988 t-Transglutaminase (tTG) IgG 32998-7 164989 t-Transglutaminase (tTG) IgG U/mL 32998-7

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