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COVID-19 Poor Outcomes Risk Profile

CPT: 82728; 83615; 85025; 85379
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Test Includes

D-Dimer; Ferritin, Serum; Lactic Acid Dehydrogenase (LD); Neutrophil to Lymphocyte Ratio (NLR), Complete Blood Count (CBC) With Differential and Platelet


Related Documents


Specimen Requirements


Specimen

Serum, plasma, and whole blood


Volume

3 mL serum, 2 mL plasma (sodium citrate), and 4 mL whole blood (EDTA)


Minimum Volume

2 mL serum, 1 mL plasma (sodium citrate), and 4 mL whole blood (Note: This volume does not allow for repeat testing.)


Container

Gel-barrier tube, blue-top (sodium citrate) tube, and lavender-top (EDTA) tube


Collection

Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells.Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze plasma within four hours of blood collection and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit seperate frozen specimens for each test requested.


Storage Instructions

Frozen: Plasma

Room temperature: Serum and whole blood (EDTA)


Test Details


Use

Assessment of patients at risk of mortality from COVID-19 disease


Methodology

See individual test components.


References

Aloisio E, Chibireva M, Serafini L, et al. A Comprehensive Appraisal of Laboratory Biochemistry Tests as Major Predictors of COVID-19 Severity. Arch Pathol Lab Med. 2020 Dec 1;144(12):1457-1464.32649222
Cicculo A, Borghetti A, Dal Verme LZ, et al. Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. Int J Antimicrob Agents. 2020 Aug;56(2):106017.32437920
Gao Y, Li T, Han M, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020 Jul;92(7):791-796.32181911
Kerboua KE. NLR: A Cost-effective Nomogram to Guide Therapeutic Interventions in COVID-19. Immunol Invest. 2021 Jan;50(1):92-100.32482134
Tatum D, Taghavi S, Houghton A, Stover J, Toraih E, Duchesne J. Neutrophil-to-lymphocyte ratio and outcomes in Louisiana COVID-19 patients. Shock. 2020 Nov;54(5):652-658.32554992
Tjendra Y, Al Mana AF, Espejo AP, et al. Predicting Disease Severity and Outcome in COVID-19 Patients. Arch Pathol Lab Med. 2020 Dec 1;144(12):1465-1474.32818235
Velavan TP, Meyer CG. Mild versus severe COVID-19: Laboratory markers. Int J Infect Dis. 2020 Jun;95:304-307.32344011
Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020 Jul;84:106504.32304994

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164081 COVID-19 Poor Outcomes Risk 001115 LDH IU/L 2532-0
164081 COVID-19 Poor Outcomes Risk 004598 Ferritin, Serum ng/mL 2276-4
164081 COVID-19 Poor Outcomes Risk 115206 D-Dimer mg/L FEU 48065-7
164081 COVID-19 Poor Outcomes Risk 005025 WBC x10E3/uL 6690-2
164081 COVID-19 Poor Outcomes Risk 005033 RBC x10E6/uL 789-8
164081 COVID-19 Poor Outcomes Risk 005041 Hemoglobin g/dL 718-7
164081 COVID-19 Poor Outcomes Risk 005058 Hematocrit % 4544-3
164081 COVID-19 Poor Outcomes Risk 015065 MCV fL 787-2
164081 COVID-19 Poor Outcomes Risk 015073 MCH pg 785-6
164081 COVID-19 Poor Outcomes Risk 015081 MCHC g/dL 786-4
164081 COVID-19 Poor Outcomes Risk 105007 RDW % 788-0
164081 COVID-19 Poor Outcomes Risk 015172 Platelets x10E3/uL 777-3
164081 COVID-19 Poor Outcomes Risk 015107 Neutrophils % 770-8
164081 COVID-19 Poor Outcomes Risk 015123 Lymphs % 736-9
164081 COVID-19 Poor Outcomes Risk 015131 Monocytes % 5905-5
164081 COVID-19 Poor Outcomes Risk 015149 Eos % 713-8
164081 COVID-19 Poor Outcomes Risk 015156 Basos % 706-2
164081 COVID-19 Poor Outcomes Risk 115398 Immature Cells n/a
164081 COVID-19 Poor Outcomes Risk 015909 Neutrophils (Absolute) x10E3/uL 751-8
164081 COVID-19 Poor Outcomes Risk 015917 Lymphs (Absolute) x10E3/uL 731-0
164081 COVID-19 Poor Outcomes Risk 015912 Neut/Lymph Ratio ratio n/a
164081 COVID-19 Poor Outcomes Risk 015925 Monocytes(Absolute) x10E3/uL 742-7
164081 COVID-19 Poor Outcomes Risk 015933 Eos (Absolute) x10E3/uL 711-2
164081 COVID-19 Poor Outcomes Risk 015941 Baso (Absolute) x10E3/uL 704-7
164081 COVID-19 Poor Outcomes Risk 015108 Immature Granulocytes % 71695-1
164081 COVID-19 Poor Outcomes Risk 015911 Immature Grans (Abs) x10E3/uL 53115-2
164081 COVID-19 Poor Outcomes Risk 015945 NRBC % 58413-6
164081 COVID-19 Poor Outcomes Risk 015180 Hematology Comments: 18314-5
164081 COVID-19 Poor Outcomes Risk 164082 Poor Outcomes Risk Panel n/a
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115400 Bands % 35332-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115401 Metamyelocytes % 28541-1
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115403 Myelocytes % 26498-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115404 Promyelocytes % 26498-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115405 Blasts/blast like cells % 26498-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115406 Megakaryocytes % 19252-6
Reflex Table for Immature Cells
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115399 Immature Cells 115265 Other, Lineage Uncertain % 55433-7

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf