Liver-Kidney Microsomal (LKM) Antibodies

CPT: 86376
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  • LKM
  • LKM-1 Antibodies

Expected Turnaround Time

2 - 3 days

Related Documents

Specimen Requirements




1 mL

Minimum Volume

0.3 mL


Red-top tube or gel-barrier tube


To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x4

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added

Test Details


The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease. The disease is most common between the ages of 2 to 14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.


A negative LKM-1 result does not rule out the presence of autoimmune hepatitis type 2. LKM-1 may be detected in some patients as a result of HCV infection and may not be the result of AIH-2.


Enzyme-linked immunosorbent assay (ELISA)

Reference Interval

• Negative: 0.0−20.0

• Equivocal: 20.1−24.9

• Positive: >24.9


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163980 Liver-Kidney Microsomal Ab 32220-6 163982 Liver-Kidney Microsomal Ab Units 32220-6

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