Antineutrophil Cytoplasmic Antibody (ANCA) Profile

CPT: 83516(x2); 86037(x3)
83516(x2); 86037(x3)83516(x2); 86037(x3)
83516(x2); 86037(x3)83516(x2); 86037(x3)
Updated on 09/20/2022
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Synonyms

  • MPO-ANCA
  • PR3-ANCA

Expected Turnaround Time

4 - 7 days

3 - 7 days

4 - 7 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

3 mL


Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination


Test Details


Use

For diagnosis and monitoring inflammatory activity in primary systemic small vessel vasculitides. The anti-PR3-ANCA Immunoassay is useful for confirming positive ANCA results by IFA, particularly with the cANCA pattern. Presence of anti-PR3 antibodies is highly specific for Wegener granulomatous (WG) disease, for which the sensitivity is reported to be 98%. Levels of anti-PR3 are elevated during active phases of disease and lower during remission. Monitoring anti-PR3 levels, therefore, can aid in disease management. The anti-MPO-ANCA Immunoassay is useful for confirming positive ANCA results by IFA, particularly with the P-ANCA pattern. Presence of anti-MPO antibodies is highly specific for idiopathic and vasculitis-associated crescentic glomerulonephritis, classic polyarteritis nodosa, Churg-Strauss syndrome, and polyangiitis overlap syndrome without renal involvement. Levels of anti-MPO are elevated during active phases of disease and lower during remission. Therefore, monitoring anti-MPO levels can aid in disease management.


Methodology

ANCA: indirect fluorescent antibody (IFA); MPO and PR3: Multiplex Flow Immunoassay


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163061 ANCA Profile 163060 Anti-MPO Antibodies units 46266-3
163061 ANCA Profile 163068 Anti-PR3 Antibodies units 46267-1
163061 ANCA Profile 162400 Cytoplasmic (C-ANCA) titer 14277-8
163061 ANCA Profile 162401 Perinuclear (P-ANCA) titer 14278-6
163061 ANCA Profile 162402 Atypical pANCA titer 49503-6

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