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- p-ANCA-Specific Antibodies
Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Test Details
Use
Antibodies against myeloperoxidase (MPO) are referred to as p-ANCA subtype, since they form a perinuclear fluorescence pattern. This ANCA-fluorescent (antineutrophil cytoplasmic antibodies) subtype includes other antibodies such as antibodies against lactoferrin, cathepsin G or elastase. However, in at least 60% of p-ANCA reactivity cases, the main antigen is MPO. Anti-MPO antibodies are primarily considered an important indicator for progressing nephritis; they are largely present in patients with severe renal impairment. They are also important for diagnosing Churg-Strauss syndrome and microscopic polyangiitis. The presence or absence of antibodies against MPO and PR3 in combination with the positivity of antinuclear antibodies may be regarded as a differentiating marker between ANCA-associated vasculitis and SLE-induced vasculitis.
Methodology
Multiplex flow immunoassay
Reference Interval
0.0–0.9
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 163059 | Anti-MPO Antibodies | 46266-3 | 163060 | Anti-MPO Antibodies | units | 46266-3 |
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