LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.


CPT: 86235
Updated on 01/29/2020
Print Share


  • Polymyositis
  • t-RNA Synthetase

Test Includes

Semiquantitative result of IgG class antibodies

Semiquantitative result of IgG class antibodies

Expected Turnaround Time

1 - 3 days

Related Documents

Specimen Requirements




0.6 mL

Minimum Volume

0.3 mL


Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination

Test Details


Evaluate patients suspected of having polymyositis, dermatomyositis, or polymyositis-scleroderma overlap syndrome


Multiplex flow immunoassay

Reference Interval

0.0−0.9 AI

Additional Information

Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment. Testing for ANAs is not adequate for the detection of anti-Jo-1 antibodies.


Bernstein RM, Morgan SH, Chapman J, et al. Anti-Jo-1 antibody: A marker for myositis with interstitial lung disease. Br Med J (Clin Res Ed). 1984 Jul 21; 289(6438):151-152. 6430389
Hochberg MC, Feldman D, Stevens MB, Arnett FC, Reichlin M. Antibody to Jo-1 in polymyositis/dermatomyositis: Association with interstitial pulmonary disease. J Rheumatol. 1984 Oct; 11(5):663-665. 6334746


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
161455 Anti-Jo-1 11565-9 161457 Anti-Jo-1 AI 11565-9

For Providers

Please login to order a test

Order a Test

© 2020 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at