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Anti-Jo-1

CPT: 86235
Updated on 01/29/2020
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Synonyms

  • Polymyositis
  • t-RNA Synthetase

Test Includes

Semiquantitative result of IgG class antibodies

Semiquantitative result of IgG class antibodies


Expected Turnaround Time

1 - 3 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

0.6 mL


Minimum Volume

0.3 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination


Test Details


Use

Evaluate patients suspected of having polymyositis, dermatomyositis, or polymyositis-scleroderma overlap syndrome


Methodology

Multiplex flow immunoassay


Reference Interval

0.0−0.9 AI


Additional Information

Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease. In such patients, the presence of anti-Jo-1 antibodies may be predictive of a response to steroid treatment. Testing for ANAs is not adequate for the detection of anti-Jo-1 antibodies.


References

Bernstein RM, Morgan SH, Chapman J, et al. Anti-Jo-1 antibody: A marker for myositis with interstitial lung disease. Br Med J (Clin Res Ed). 1984 Jul 21; 289(6438):151-152. 6430389
Hochberg MC, Feldman D, Stevens MB, Arnett FC, Reichlin M. Antibody to Jo-1 in polymyositis/dermatomyositis: Association with interstitial pulmonary disease. J Rheumatol. 1984 Oct; 11(5):663-665. 6334746

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
161455 Anti-Jo-1 11565-9 161457 Anti-Jo-1 AI 11565-9

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