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Herpes Simplex Virus (HSV) Types 1/2, Cerebrospinal Fluid (CSF), DNA PCR
CPT:
87529(x2)
Synonyms
- HSV PCR
- HSV-1 PCR
- HSV-2 PCR
Special Instructions
This test code is intended for cerebrospinal fluid (CSF) only.
Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Cerebrospinal fluid (CSF)
Volume
0.5 mL CSF
Minimum Volume
0.2 mL CSF
Container
Sterile container
Collection
To avoid delays in turnaround time when requesting multiple tests on frozen sample, please submit separate specimens for each test requested.
Storage Instructions
Frozen
Causes for Rejection
Improperly labeled or unlabeled specimen; specimen that has grossly leaked in transit; specimen submitted in an improper collection/transport device; non-CSF specimens
Test Details
Use
This assay is used for the detection and differentiation of HSV-1 and HSV-2 DNA in cerebrospinal fluid.
Limitations
Results from this test must be considered in conjunction with the clinical history, epidemiological data and other laboratory information available to the clinician evaluating the patient.
Negative results do not rule out HSV infections of the CNS and should not be used as the sole basis for treatment or other patient management decisions.
False-negative results may occur if the viruses are present at a level that is below the analytical sensitivity of the assay or if the virus has genomic mutations, insertions, deletions, or rearrangements or if performed very early in the course of illness.
For encephalitis patients with a negative herpes simplex PCR result, consideration should be given to repeating the test 3 - 7 days later for patients demonstrating a compatible syndrome or temporal lobe localization on neuroimaging.
Methodology
Real-time PCR
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf