Pancreatic Elastase, Fecal

CPT: 82653
8265382653
8265382653
Updated on 11/18/2022
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Synonyms

  • Elastase, Pancreatic

Expected Turnaround Time

4 - 6 days


Related Documents


Specimen Requirements


Specimen

Stool (unpreserved, random)


Volume

3 g


Minimum Volume

1 g (Note: This volume does not allow for repeat testing.)


Container

Screw-capped plastic vial


Collection

Do not contaminate outside of container. Do not overfill container. Do not submit watery or unformed (loose) stool. Do not use a preservative.


Storage Instructions

Specimens should be transported refrigerated (ice packs) or frozen if transport temperature is expected to exceed 40°C (104°F).


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Patient Preparation

This assay does not measure the substituted enzyme (Pancreatin) and, therefore, it is not necessary to stop medication before taking a sample.

This assay does not measure the substituted enzyme (Pancreatin) and, therefore, it is not necessary to stop medication before taking a sample.


Causes for Rejection

Serum or plasma received; stool contaminated with urine; preserved stool received

Serum or plasma received; stool contaminated with urine; watery or unformed (loose) stool submitted; preserved stool received

Serum or plasma received; stool contaminated with urine; preserved stool received; preserved stool received


Test Details


Use

Can be used for the diagnosis or the exclusion of exocrine pancreatic insufficiency, which may be associated with chronic pancreatitis, cystic fibrosis, carcinoma of the pancreas, diabetes mellitus type 1 (insulin-dependent diabetes mellitus), Shwachman-Diamond syndrome, and other etiologies of pancreatic insufficiency.


Methodology

Enzyme-linked immunosorbent assay (ELISA) based upon a monoclonal antibody-based detection system specific for pancreatic elastase-1 (PEL-1)


Reference Interval

• Normal: >200 μg elastase/g fecal material

• Moderate pancreatic insufficiency: 100−200 μg elastase/g fecal material

• Severe pancreatic insufficiency: <100 μg elastase/g fecal material


Additional Information

The polyclonal antibodies used in this assay are specifically directed against defined sequences of the human pancreatic elastase molecule. The enzyme stability is remarkably high despite its proteolytic activity, as elastase is found in feces in about a sixfold concentration as in pancreatic fluid. The determination of enzyme concentration in feces reflects the exocrine secretory capacity of the pancreas.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123234 Pancreatic Elastase, Fecal 25907-7 123236 Pancreatic Elastase, Fecal ug Elast./g 25907-7

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