Pancreatic Elastase, Fecal

TEST: 123234
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CPT: 82653
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Synonyms

  • Elastase, Pancreatic

Expected Turnaround Time

4 - 6 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Stool (unpreserved, random)

Volume

3 g

Minimum Volume

1 g (Note: This volume does not allow for repeat testing.)

Container

Screw-capped plastic vial

Collection

Do not contaminate outside of container. Do not overfill container. Do not use a preservative.

Storage Instructions

Specimens should be transported refrigerated (ice packs) or frozen if transport temperature is expected to exceed 40°C (104°F).

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Patient Preparation

This assay does not measure the substituted enzyme (Pancreatin) and, therefore, it is not necessary to stop medication before taking a sample.

Causes for Rejection

Serum or plasma received; stool contaminated with urine; preserved stool received

Test Details

Use

Can be used for the diagnosis or the exclusion of exocrine pancreatic insufficiency, which may be associated with chronic pancreatitis, cystic fibrosis, carcinoma of the pancreas, diabetes mellitus type 1 (insulin-dependent diabetes mellitus), Shwachman-Diamond syndrome, and other etiologies of pancreatic insufficiency.

Methodology

Enzyme-linked immunosorbent assay (ELISA) based upon a monoclonal antibody-based detection system specific for pancreatic elastase-1 (PEL-1)

Reference Interval

• Normal: >200 μg elastase/g fecal material

• Moderate pancreatic insufficiency: 100−200 μg elastase/g fecal material

• Severe pancreatic insufficiency: <100 μg elastase/g fecal material

Additional Information

The polyclonal antibodies used in this assay are specifically directed against defined sequences of the human pancreatic elastase molecule. The enzyme stability is remarkably high despite its proteolytic activity, as elastase is found in feces in about a sixfold concentration as in pancreatic fluid. The determination of enzyme concentration in feces reflects the exocrine secretory capacity of the pancreas.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123234 Pancreatic Elastase, Fecal 25907-7 123236 Pancreatic Elastase, Fecal ug Elast./g 25907-7

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf