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Disseminated Intravascular Coagulation (DIC) Profile

CPT: 85049; 85362; 85379; 85384; 85610; 85730
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  • DIC Profile

Test Includes

D-dimer; fibrinogen; fibrinogen degradation products (FDP), plasma; platelet count; partial thromboplastin time (PTT); prothrombin time (PT)

Special Instructions

If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.

Expected Turnaround Time

2 - 3 days

Related Documents

For more information, please view the literature below.

Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium

Specimen Requirements


Whole blood and plasma, frozen


5 mL EDTA whole blood, one citrated whole blood tube, and two transfer tubes with 1 mL frozen sodium citrate plasma in each tube


Lavender-top (EDTA) tube and blue-top (sodium citrate) tubes


Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells. Transfer the plasma into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp No. 49482). Freeze immediately and maintain frozen until tested.

Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

Storage Instructions

Maintain whole blood at room temperature. Freeze plasma.

Patient Preparation


Causes for Rejection

Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability

Test Details


Identify the presence and follow the course of disseminated intravascular coagulation (DIC)


See individual tests.


1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol. 1997 Jan; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, Ng VL, Gottfried EL. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998 Jun; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997 Jun; 107(6):681-683. 9169665
5. McGlasson DL, More L, Best HA, Norris WL, Doe RH, Ray H. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999 May-Jun; 12(3):137-139. 10539100


Carey MJ, Rodgers GM. Disseminated intravascular coagulation: Clinical and laboratory aspects. Am J Hematol. 1998 Sep; 59(1):65-73. 9723580
Mammen EF. Disseminated intravascular coagulation (DIC). Clin Lab Sci. 2000 Fall; 13(4):239-245. 11586511
Yu M, Nardella A, Pechet L. Screening tests of disseminated intravascular coagulation: Guidelines for rapid and specific laboratory diagnosis. Crit Care Med. 2000 Jun; 28(6):1777-1780. 10890618


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
116012 DIC Profile 001610 Fibrinogen Activity mg/dL 3255-7
116012 DIC Profile 115402 FDP, Plasma ug/mL 30226-5
116012 DIC Profile 115107 INR 6301-6
116012 DIC Profile 015289 Prothrombin Time sec 5902-2
116012 DIC Profile 015116 aPTT sec 14979-9
116012 DIC Profile 015172 Platelets x10E3/uL 777-3
116012 DIC Profile 115206 D-Dimer mg/L FEU 48065-7
Reflex Table for INR
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115109 INR (Thromborel-S) 115109 INR (Thromborel-S) 6301-6
Reflex Table for Prothrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 015290 PT (Thromborel-S) 015290 PT (Thromborel-S) sec 5902-2

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