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Acid-fast (Mycobacteria) Antibiotic Susceptibilities
CPT:
87190(x4). Variable depending on identification.
Synonyms
- AFB Susceptibility Testing
- Rapid-grower Susceptibility Testing
- Susceptibility Testing, AFB
- TB Susceptibility Testing
Test Includes
Antimycobacterial agents tested against isolates at appropriate concentrations and drugs depending on identification of the isolate. Identification is required to perform or provide an accurate interpretation for susceptibility testing, it will be done at an additional charge automatically.
Special Instructions
Culture must be in special etiologic agent packaging for shipment to LabCorp.
Expected Turnaround Time
40 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
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40 days |
Related Information
Specimen Requirements
Specimen
Isolated mycobacteria from primary clinical specimen on media slant or in broth
Container
Media slant, tightly sealed, in etiologic agent packaging
Storage Instructions
Maintain culture at room temperature.
Causes for Rejection
Specimen received leaking or in broken transport tube or vial; specimen received in expired transport media; mixed culture; unlabeled culture or name discrepancy between specimen and request label
Test Details
Use
Determine the susceptibility of the isolated organism to a profile of antimycobacterial agents
Limitations
Susceptibilities cannot be reported if the organism fails to grow on test media.
Methodology
Bactec® or other broth-based method, conventional proportion method. Newer methods (eg, MIC) will be introduced when validated.
Additional Information
Susceptibilities should be performed on the first organism isolated from a patient, and at one- to three-month intervals if that organism continues to be isolated while the patient is on therapy. Susceptibility tests should be performed in patients with recurrent tuberculosis as resistant strains are common in recurrent infection. Outbreaks have occurred in health care workers, prison inmates, and prison employees.1,2 Failure to take all drugs in a multidrug regimen can lead to a shift toward resistant organisms and treatment failure. Nontuberculous mycobacteria, particularly strains of the M avium complex, are resistant to those drugs used for therapy of M tuberculosis.3
Footnotes
1. Beck-Sague C, Dooley Sw, Hutton MD, et al. Hospital outbreak of multidrug-resistant Mycobacterium tuberculosis infections. Factors in transmission to staff and HIV-infected patients. JAMA. 1992 Sep 9; 268(10):1280-1286. 1507374
2. Dooley SW, Villarino ME, Lawrence M, et al. Nosocomial transmission of tuberculosis in a hospital unit for HIV-infected patients. JAMA. 1992 May 20; 267(19):2632-2634. 1573751
3. Wolinsky E. Mycobacterial diseases other than tuberculosis. Clin Infect Dis. 1992 Jul; 15(1):1-10. 1617048
References
Heifets L. Qualitative and quantitative drug-susceptibility tests in mycobacteriology. Am Rev Respir Dis. 1988 May; 137(5):1217-1222. 3195815
Mor N, Heifets L. MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages. Antimicrob Agents Chemother. 1993 Jan; 37(1):111-114. 8431006
Rastogi N, Goh KS. Effect of pH on radiometric MICs of clarithromycin against 18 species of mycobacteria. Antimicrob Agents Chemother. 1992 Dec; 36(12):2841-2842. 1482156
Van Scoy RE, Wilkowske CJ. Antituberculous agents. Mayo Clin Proc. 1992 Feb; 67(2):179-187. 1347579
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 088161 | AFB Antibiotic Suscep | 9825-1 | 088161 | AFB Antibiotic Suscep | 9825-1 |
| Reflex Table for AFB Antibiotic Suscep | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 080543 | Result | 080544 | Result 1 | 9825-1 | |
| Reflex Table for AFB Antibiotic Suscep | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 080543 | Result | 080545 | Result 2 | n/a | |
| Reflex Table for AFB Antibiotic Suscep | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 080543 | Result | 080546 | Result 3 | n/a | |
| Reflex Table for AFB Antibiotic Suscep | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 080543 | Result | 080547 | Result 4 | n/a | |
| Reflex Table for AFB Antibiotic Suscep | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 080543 | Result | 080548 | Antimicrobial Susceptibility | 23658-8 | |
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