Syphilis: Treponemal Antibodies, Chemiluminescence Immunoassay

CPT: 86780
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  • Syphilis
  • Treponemal

Expected Turnaround Time

1 - 3 days

Related Documents

Specimen Requirements




1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; plasma specimen

Test Details


This test detects antibodies to Treponema pallidum and can be used in conjunction with a nontreponemal assay to aid in the diagnosis of syphilis infection. This test is not recommended as a stand-alone test for general screening purposes for syphilis, nor should it be used to evaluate response to therapy. To screen for and diagnose syphilis infection, a reflex cascade that includes both RPR and a treponemal-specific assay should be utilized per current guidelines.


Treponemal antibodies typically persist for life despite treatment; thus, this assay cannot be used to monitor response to treatment or to assess treatment outcomes. False positive treponemal antibody results have been observed in individuals with nonsyphilis treponemal infections (bejel, pinta, yaws).


Chemiluminescent immunoassay (CLIA)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
082370 Treponema pallidum Antibodies 47236-5 082372 Treponema pallidum Antibodies 47236-5

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