Antichromatin Antibodies

TEST: 012580
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CPT: 86235
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Synonyms

  • Antibodies to LE Cell Phenomenon

Expected Turnaround Time

1 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube or red-top tube

Collection

If tube other than gel-barrier tube is used, transfer the separated serum to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis

Test Details

Use

Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE). Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.

Methodology

Multiplex flow immunoassay

References

Burlingame RW, Cervera R. Anti-chromatin (anti-nucleosome) autoantibodies. Autoimmun Rev. 2002 Dec; 1(6):321-328. 12848987
Sherer Y, Gorstein A, Fritzler MJ, Schoenfeld Y. Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients. Semin Arthritis Rheum. 2004 Oct; 34(2):507-537. 15505768
Simón JA, Cabiedes J, Ortiz E, Alcocer-Varela J, Sánchez-Guerrero J. Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker. Rheumatology (Oxford). 2004 Feb; 43(2):220-224. 13130152
Stinton LM, Barr SG, Tibbles LA, et al. Autoantibodies in lupus nephritis patients requiring renal transplantation. Lupus. 2007; 16(6):394-400. 17664229
Villata D, Tozzoli R. Anti-chromatin (nucleosome) autoantibodies. In: Gershwin ME, Meroni P-L, Schoenfeld Y, eds. Autoantibodies. 2nd ed. Amsterdam, The Netherlands: Elsevier, BV; 2007:141-149.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
012580 Antichromatin Antibodies 51775-5 012581 Antichromatin Antibodies AI 51775-5

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf