Actin (Smooth Muscle) Antibody (ASMA)

CPT: 86015
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Synonyms

  • Antiactin
  • Smooth Muscle Antibodies

Expected Turnaround Time

2 - 3 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.3 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added


Test Details


Use

Detection of antibodies aids in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC)


Limitations

Antiactin antibodies have been reported at low levels in 3% to 18% of sera from the general healthy population. The presence of immune complexes in the patient's sample may produce false positives in this assay. Not all smooth muscle positive samples will have actin antibodies.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


Reference Interval

• Negative: 0−19

• Weak positive: 20−30

• Moderate to strong positive: >30


Additional Information

Actin antibodies are found in 52% to 85% of patients with autoimmune hepatitis or chronic active hepatitis and in 22% of patients with primary biliary cirrhosis.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006643 Actin (Smooth Muscle) Antibody 44706-0 006644 Actin (Smooth Muscle) Antibody Units 44706-0

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