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- Infectious Mononucleosis Antibodies
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Test Details
Use
Detect heterophil antibodies related to infectious mononucleosis
Limitations
Rare patients may have positive heterophil agglutinins after a negative initial test. Ten percent of cases of true EBV mononucleosis may have negative heterophil agglutinins. These may be diagnosed with EBV specific tests.
Methodology
Latex agglutination (LA)
Reference Interval
Negative
Additional Information
A positive test in the presence of consistent clinical and/or hematologic findings confirms the diagnosis of infectious mononucleosis. Approximately 10% of mononucleosis syndromes are heterophil-negative. In some of these, antibody to specific Epstein-Barr viral antigen can be demonstrated. Others may be due to CMV, HSV, or toxoplasmosis. Although this classic test has excellent specificity, false-positive tests can occur and may lead to diagnostic confusion.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006189 | Mononucleosis Test, Qual | 5213-4 | 006189 | Mononucleosis Test, Qual | 5213-4 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf