Mononucleosis Test, Qualitative

CPT: 86308
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  • Infectious Mononucleosis Antibodies

Expected Turnaround Time

1 - 2 days

Related Documents

Specimen Requirements




1 mL

Minimum Volume

0.5 mL


Red-top tube or gel-barrier tube

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Test Details


Detect heterophil antibodies related to infectious mononucleosis


Rare patients may have positive heterophil agglutinins after a negative initial test. Ten percent of cases of true EBV mononucleosis may have negative heterophil agglutinins. These may be diagnosed with EBV specific tests.


Latex agglutination (LA)

Reference Interval


Additional Information

A positive test in the presence of consistent clinical and/or hematologic findings confirms the diagnosis of infectious mononucleosis. Approximately 10% of mononucleosis syndromes are heterophil-negative. In some of these, antibody to specific Epstein-Barr viral antigen can be demonstrated. Others may be due to CMV, HSV, or toxoplasmosis. Although this classic test has excellent specificity, false-positive tests can occur and may lead to diagnostic confusion.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006189 Mononucleosis Test, Qual 5213-4 006189 Mononucleosis Test, Qual 5213-4

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