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Mononucleosis Test, Qualitative

CPT: 86308
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Synonyms

  • Infectious Mononucleosis Antibodies

Expected Turnaround Time

1 - 2 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Maintain specimen at room temperature.


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Test Details


Use

Detect heterophil antibodies related to infectious mononucleosis


Limitations

Rare patients may have positive heterophil agglutinins after a negative initial test. Ten percent of cases of true EBV mononucleosis may have negative heterophil agglutinins. These may be diagnosed with EBV specific tests.


Methodology

Latex agglutination (LA)


Reference Interval

Negative


Additional Information

A positive test in the presence of consistent clinical and/or hematologic findings confirms the diagnosis of infectious mononucleosis. Approximately 10% of mononucleosis syndromes are heterophil-negative. In some of these, antibody to specific Epstein-Barr viral antigen can be demonstrated. Others may be due to CMV, HSV, or toxoplasmosis. Although this classic test has excellent specificity, false-positive tests can occur and may lead to diagnostic confusion.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006189 Mononucleosis Test, Qual 5213-4 006189 Mononucleosis Test, Qual 5213-4

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf