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Antibody Screen

CPT: 86850
Updated on 05/18/2019
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Synonyms

  • Indirect Antiglobulin Test
  • Indirect Coombs'

Test Includes

Red cell antibody screening. Note: Identification of antibody(ies) and titer of clinically significant antibody(ies) will be automatically performed at an additional charge if the antibody screen is positive.

Red cell antibody screening. Note: Identification of antibody(ies) and titer of clinically significant antibody(ies) will be automatically performed at an additional charge if the antibody screen is positive.


Expected Turnaround Time

1 - 2 days


Related Documents


Specimen Requirements


Specimen

Whole blood (Note: This should not be a shared specimen. If antibody identification is necessary, the entire volume of this lavender-top tube will be required.)


Volume

4 mL


Minimum Volume

1 mL (Note: This minimum amount will not allow for antibody identification if the antibody screen is positive.)


Container

Lavender-top (EDTA) tube


Storage Instructions

Specimens should be tested as soon as possible or within 72 hours of collection. Samples that cannot be tested immediately should be stored at 2°C to 8°C. Do not freeze red cells.


Causes for Rejection

Gross hemolysis; bacterial or other contamination


Test Details


Use

Detect atypical IgG antibodies prior to transfusion or during pregnancy. The technique is designed specifically to detect IgG antibodies, though on occasion, some IgM antibodies may also be detected. Antibodies detected by the antibody screen will be subsequently identified, and a titer performed if the antibody identified is considered to be clinically significant during pregnancy.


Limitations

No antibody screening test will detect all antibodies. This method may not detect IgM antibodies or antibodies to low frequency antigens. Extremely low-titered antibodies may be detected but may be too weak to identify.


Methodology

Antiglobulin test


Contraindications

Specimens known to test positive for red cell antibody screening should not be submitted for antibody screen testing. In order to facilitate proper routing and testing, Antibody Identification (006213) should be ordered. This test should not be ordered for the husband or partner of a prenatal patient since antibodies detected in the serum or plasma of these individuals are irrelevant during pregnancy.

Reference Interval

Negative


References

Fung MK, Grossman JB, Hillyer CD, Westoff CM, eds. AABB Technical Manual. 18th ed. Bethesda, Md: American Association of Blood Banks;2014.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006015 Antibody Screen 890-4 006015 Antibody Screen 890-4
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 114033 Antibody Screen 890-4
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019786 Antibody Id. #1 888-8
Reflex 2 114108 Ab Scr+Antibody ID 114034 Antibody Screen 890-4
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019786 Antibody Id. #1 888-8
Reflex 2 114108 Ab Scr+Antibody ID 114035 Antibody Id. #1 888-8
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019786 Antibody Id. #1 888-8
Reflex 2 114108 Ab Scr+Antibody ID 114036 Coombs Titer #1 50970-3
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019786 Antibody Id. #1 888-8
Reflex 2 114108 Ab Scr+Antibody ID 114037 Antibody Id. #2 888-8
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019786 Antibody Id. #1 888-8
Reflex 2 114108 Ab Scr+Antibody ID 114038 Coombs Titer #2 50970-3
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019802 Coombs Titer #1 50970-3
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019810 Antibody Id. #2 888-8
Reflex Table for Antibody Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 114041 Ab Scr+Antibody ID 019836 Coombs Titer #2 50970-3

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