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Protein and Creatinine, Random Urine

CPT: 82570; 84156
Updated on 12/9/2019
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Test Includes

Creatinine; protein, total; protein:creatinine ratio

Creatinine; protein, total; protein:creatinine ratio


Expected Turnaround Time

Within 1 day


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Specimen Requirements


Specimen

Urine (random)


Volume

50 mL


Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)


Container

Plastic urine container, no preservative


Collection

Collect random urine in a clean plastic container. Label the urine container with the patient's full name and the date and time of collection.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Test Details


Use

Protein:creatinine ratio in a first-morning or random untimed "spot" urine specimen is recommended testing to ascertain chronic kidney disease.1 It is also used to evaluate nephrotic syndromes; work up other renal diseases, including malignant hypertension, glomerulonephritis, Goodpasture syndrome, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia; tubular proteinurias, including Wilson's disease and Fanconi syndrome. Albumin/Creatinine Ratio, Random Urine is a more sensitive marker of progression and regression of renal disease than urine total protein, especially when urine total protein is <300 mg/g creatinine.


Methodology

Spectrophotometric


Footnotes

1. Kidney Disease Outcomes Quality Initiative (K/DOQI). K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease.Am J Kidney Dis. 2004 May; 43(5 Suppl 1):S1-290. 15114537

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
003129 Prot+CreatU (Random) 013672 Creatinine, Urine mg/dL 2161-8
003129 Prot+CreatU (Random) 013664 Protein,Total,Urine mg/dL 2888-6
003129 Prot+CreatU (Random) 100203 Protein/Creat Ratio mg/g creat 2890-2

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