VDRL, Cerebrospinal Fluid

CPT: 86592
Print Share

Test Details


  • CSF Venereal Disease Research Laboratory (VDRL) Test


Test for syphilis, neurosyphilis



Reference Interval


Additional Information

A positive VDRL in a spinal fluid uncontaminated by serum is essentially diagnostic of neurosyphilis; however, a negative test may occur in 30% of patients with tabes dorsalis. The CSF VDRL may take years to become nonreactive after adequate therapy. In AIDS patients, serial CSF VDRL determinations may be needed when neurosyphilis is suspected. By requiring either a positive plasma RPR or FTA-ABS, seropositivity of CSF VDRL could increase to 90%.

Specimen Requirements


Cerebrospinal fluid (CSF)


1 mL

Minimum Volume

0.5 mL


Sterile tube

Storage Instructions


Causes for Rejection

Hemolysis; gross bacterial contamination


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006445 VDRL, CSF 22459-2 006445 VDRL, CSF 22459-2

For Providers

Please login to order a test.


© 2018  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf