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Vanillylmandelic Acid (VMA), Random Urine
- 3-Methoxy-4-Hydroxymandelic Acid
- VMA, Random Urine
Creatinine, urine; VMA, urine (mg/L); VMA:creatinine ratio
Pediatric testing for the evaluation of hypertension; diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Pediatric patients1 and adults: VMA:creatinine ratio
• Up to 2 years: 0.0−18.8 mg/g creatinine
• 2 to 4 years: 0.0−11.0 mg/g creatinine
• 5 to 9 years: 0.0−8.3 mg/g creatinine
• 10 to 19 years: 0.0−8.2 mg/g creatinine
• Older than 19 years: 0.0−6.0 mg/g creatinine
Some neuroblastoma patients are positive for urinary homovanillic acid abnormality but do not excrete increased VMA. Twenty percent to 32% of patients with neuroblastoma do not have elevation of VMA. Many will have other laboratory abnormalities such as increased metanephrines, homovanillic acid (HVA), or dopamine.
10 mL aliquot
1 mL aliquot
Plastic urine container
Patient should avoid salicylates, caffeine, phenothiazine, and antihypertension agents. Also coffee, tea, chocolate, fruit (especially bananas and any vanilla-containing substances for 72 hours prior to collection).
If specimen is to be stored for longer than seven days before analysis, use random urine transport tube.
Vanillylmandelic acid is stable at room temperature (15°C to 30°C) unpreserved for seven days.
Use for patients where 24-hour urine collection is difficult (eg, pediatric patients). Twenty-four-hour urine collection is preferable (see Vanillylmandelic Acid (VMA), 24-Hour Urine ).
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|123208||VMA, Random Urine||070016||Creatinine, Random U||mg/dL||2161-8|
|123208||VMA, Random Urine||123209||VMA, Random Urine||mg/L||9624-8|
|123208||VMA, Random Urine||070050||VMA/Crt, Random U||mg/g Creat||3124-5|