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Vanillylmandelic Acid (VMA), Random Urine
- 3-Methoxy-4-Hydroxymandelic Acid
- VMA, Random Urine
Pediatric testing for the evaluation of hypertension; diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Pediatric patients1 and adults: VMA:creatinine ratio
• Up to 2 years: 0.0−18.8 mg/g creatinine
• 2 to 4 years: 0.0−11.0 mg/g creatinine
• 5 to 9 years: 0.0−8.3 mg/g creatinine
• 10 to 19 years: 0.0−8.2 mg/g creatinine
• Older than 19 years: 0.0−6.0 mg/g creatinine
Some neuroblastoma patients are positive for urinary homovanillic acid abnormality but do not excrete increased VMA. Twenty percent to 32% of patients with neuroblastoma do not have elevation of VMA. Many will have other laboratory abnormalities such as increased metanephrines, homovanillic acid (HVA), or dopamine.
10 mL aliquot
1 mL aliquot
If specimen is to be stored for longer than seven days before analysis, use random urine transport tube.
Use for patients where 24-hour urine collection is difficult (eg, pediatric patients). Twenty-four-hour urine collection is preferable (see Vanillylmandelic Acid (VMA), 24-Hour Urine ).
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|123208||VMA, Random Urine||070016||Creatinine, Random U||mg/dL||2161-8|
|123208||VMA, Random Urine||123209||VMA, Random Urine||mg/L||9624-8|
|123208||VMA, Random Urine||070050||VMA/Crt, Random U||mg/g Creat||3124-5|