Vanillylmandelic Acid (VMA), 24-Hour Urine

CPT: 84585
Print Share

Test Details

Synonyms

  • 3-Methoxy-4-Hydroxymandelic Acid, 24-Hour Urine
  • VMA, 24-Hour Urine

Use

Diagnose pheochromocytoma, VMA is of value for evaluation of hypertension, diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

0.0−7.5 mg/24 hours

Additional Information

Some neuroblastoma patients are positive for urinary homovanillic acid abnormality but do not excrete increased VMA. Twenty percent to 32% of patients with neuroblastoma do not have elevation of VMA. Many will have other laboratory abnormalities such as increased metanephrines, homovanillic acid (HVA), or dopamine.

Specimen Requirements

Specimen

Urine (24-hour)

Volume

4 mL aliquot

Minimum Volume

1 mL aliquot

Container

Plastic urine container

Patient Preparation

Patient should avoid salicylates, caffeine, phenothiazine, and antihypertension agents. Also coffee, tea, chocolate, fruit (especially bananas and any vanilla containing substances for 72 hours prior to collection).

Collection

Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine, including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Measure and record total urine volume. Mix well; send aliquot. Label container with patient's name, date and time collection started, and date and time collection completed.

Storage Instructions

Vanillylmandelic acid is stable at room temperature (15°C to 30°C) unpreserved for seven days.

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

Record total 24-hour urine volume on the request form.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
004143 Vanillylmandelic Acid, 24-Hr U 004144 VMA, Urine mg/L 9624-8
004143 Vanillylmandelic Acid, 24-Hr U 004145 VMA, Urine, 24hr mg/24 hr 3122-9
Reflex Table for VMA, Urine, 24hr
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 700471 Disclaimer: 700471 Disclaimer: N/A

For Providers

Please login to order a test.

 

© 2017  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf