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- 3-Methoxy-4-Hydroxymandelic Acid, 24-Hour Urine
- VMA, 24-Hour Urine
Diagnose pheochromocytoma, VMA is of value for evaluation of hypertension, diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
0.0−7.5 mg/24 hours
Some neuroblastoma patients are positive for urinary homovanillic acid abnormality but do not excrete increased VMA. Twenty percent to 32% of patients with neuroblastoma do not have elevation of VMA. Many will have other laboratory abnormalities such as increased metanephrines, homovanillic acid (HVA), or dopamine.
4 mL aliquot
1 mL aliquot
Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine, including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Measure and record total urine volume. Mix well; send aliquot. Label container with patient's name, date and time collection started, and date and time collection completed.
Vanillylmandelic acid is stable at room temperature (15°C to 30°C) unpreserved for seven days.
Record total 24-hour urine volume on the request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|004143||Vanillylmandelic Acid, 24-Hr U||004144||VMA, Urine||mg/L||9624-8|
|004143||Vanillylmandelic Acid, 24-Hr U||004145||VMA, Urine, 24hr||mg/24 hr||3122-9|