Vancomycin, Serum, Trough

CPT: 80202
Updated on 12/1/2017
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Test Details

Synonyms

  • Vancocin®

Use

Monitor therapeutic drug level

Monitor therapeutic drug level

Methodology

Immunoassay

Immunoassay

Specimen Requirements

Specimen

Serum or plasma

Serum or plasma

Volume

1 mL

1 mL

Minimum Volume

0.3 mL

0.3 mL

Container

Red-top tube or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
Red-top tube or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Collection

Transfer separated serum or plasma to a plastic transport tube. Trough concentrations should be monitored. The trough sample is drawn immediately prior to the next dose.

Transfer separated serum or plasma to a plastic transport tube. Trough concentrations should be monitored. The trough sample is drawn immediately prior to the next dose.

Storage Instructions

Refrigerate
Refrigerate

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gel-barrier tube; hemolysis; lipemia; gross bacterial contamination
Gel-barrier tube; hemolysis; lipemia; gross bacterial contamination

Clinical Information

Special Instructions

Peak levels should be ordered using test 070327. Trough levels should be ordered using test 070328. Peak and trough levels may be ordered together as a profile on the same request form using test 717314. Please label tubes appropriately as “peak” and “trough.”

References

AMA Division of Drugs and Toxicology, Drug Evaluations Subscription, Chicago, IL: American Medical Association, Spring 1990.
Brunton L, Lazo J, Parker K. Goodman & Gillman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006.
Burtis CA, Ashwood CR, Bruns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. St Louis, MO: Elsevier Saunders, 2006.
Dart RC, Caravati EM, McGuigan MA, et al. Medical Toxicology. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
Mosby's Drug Consult. 17th ed. St Louis, MO: Elsevier Saunders, 2007.
Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic Monitoring of Vancomycin in Adult Patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009 Jan 1;(66)(1)82-98.19106348
AMA Division of Drugs and Toxicology, Drug Evaluations Subscription, Chicago, IL: American Medical Association, Spring 1990.
Brunton L, Lazo J, Parker K. Goodman & Gillman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006.
Burtis CA, Ashwood CR, Bruns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. St Louis, MO: Elsevier Saunders, 2006.
Dart RC, Caravati EM, McGuigan MA, et al. Medical Toxicology. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
Mosby's Drug Consult. 17th ed. St Louis, MO: Elsevier Saunders, 2007.
Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic Monitoring of Vancomycin in Adult Patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009 Jan 1;(66)(1)82-98.19106348

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070328 Vancomycin Trough, Serum 4092-3 070338 Vancomycin Trough, Serum ug/mL 4092-3
Reflex Table for Vancomycin Trough, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 007000 See below: 007000 See below: N/A

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