ROS1 Oncology FISH

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Test Details


  • Adenocarcinoma, ROS1
  • Non−Small-cell Lung Cancer, ROS1


Confirmation/identification of cancer-related alterations in non−small-cell lung cancer


This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Fluorescence in situ hybridization (FISH)

Specimen Requirements


FNA; formalin-fixed paraffin-embedded blocks are acceptable.


Five slides (4- to 5-micron thick sections)

Minimum Volume

Two slides (4- to 5-micron thick sections)


Paraffin block

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; absence of tumor or quantity not sufficient for analysis

Clinical Information


Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012 Feb 12; 18(3):378-381.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510312 ROS1 Oncology FISH 510919 Specimen Type 31208-2
510312 ROS1 Oncology FISH 510921 Cells Counted 62361-1
510312 ROS1 Oncology FISH 510922 Cells Analyzed 62360-3
510312 ROS1 Oncology FISH 510923 FISH Result 48674-6
510312 ROS1 Oncology FISH 510308 Interpretation 62365-2
510312 ROS1 Oncology FISH 510309 Director Review: 48672-0

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