RET Oncology FISH

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Test Details

Synonyms

  • Adenocarcinoma
  • Non−Small-cell Lung Cancer

Use

Confirmation/identification of cancer-related alterations in non−small-cell lung cancer

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Specimen

FNA; formalin-fixed paraffin-embedded blocks are acceptable.

Volume

Five slides (4- to 5-micron thick sections)

Minimum Volume

Two slides (4- to 5-micron thick sections)

Container

Paraffin block

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; absence of tumor or quantity not sufficient for analysis

Clinical Information

References

Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012 Feb 12; 18(3):378-381.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510315 RET Oncology FISH 510893 Specimen Type 31208-2
510315 RET Oncology FISH 510894 Cells Counted 62361-1
510315 RET Oncology FISH 510895 Cells Analyzed 62360-3
510315 RET Oncology FISH 510896 FISH Result 48674-6
510315 RET Oncology FISH 510316 Interpretation 62365-2
510315 RET Oncology FISH 510317 Director Review 48672-0
510315 RET Oncology FISH 510298 RET FISH, Putaway N/A
Reflex Table for Interpretation
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511597 Comment: 511597 Comment: N/A

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