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- Elastase, Pancreatic
Can be used for the diagnosis or the exclusion of exocrine pancreatic insufficiency, which may be associated with chronic pancreatitis, cystic fibrosis, carcinoma of the pancreas, diabetes mellitus type 1 (insulin-dependent diabetes mellitus), Shwachman-Diamond syndrome, and other etiologies of pancreatic insufficiency.
Enzyme-linked immunosorbent assay (ELISA) based upon a monoclonal antibody-based detection system specific for pancreatic elastase-1 (PEL-1)
• Normal: >200 μg elastase/g fecal material
• Moderate pancreatic insufficiency: 100−200 μg elastase/g fecal material
• Severe pancreatic insufficiency: <100 μg elastase/g fecal material
The polyclonal antibodies used in this assay are specifically directed against defined sequences of the human pancreatic elastase molecule. The enzyme stability is remarkably high despite its proteolytic activity, as elastase is found in feces in about a sixfold concentration as in pancreatic fluid. The determination of enzyme concentration in feces reflects the exocrine secretory capacity of the pancreas.
Stool (unpreserved, random)
Do not contaminate outside of container. Do not overfill container. Do not submit watery or unformed (loose) stool. Do not use a preservative.
Refrigerate; stable for 14 days. Specimens should be transported refrigerated (ice packs) or frozen if transport temperature is expected to exceed 40°C (104°F). Stable at room temperature for three days or frozen up to one year (-20°C). Freeze/thaw cycles: x3
Causes for Rejection
Serum or plasma received; stool contaminated with urine; watery or unformed (loose) stool submitted; preserved stool received
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|123234||Pancreatic Elastase, Fecal||25907-7||123236||Pancreatic Elastase, Fecal||ug Elast./g||25907-7|