Measles, Mumps, Rubella (MMR) Immunity Profile

CPT: 86735; 86762; 86765
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Synonyms

  • MMR Antibodies

Test Includes

Measles IgG antibodies; Mumps IgG antibodies; Rubella IgG antibodies


Expected Turnaround Time

1 - 2 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

2 mL


Minimum Volume

1 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Refrigerate


Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination


Test Details


Use

Aid in the determination of serological status to measles, mumps, and rubella viruses. A positive result generally indicates exposure to virus or previous vaccination. A positive result is considered adequate laboratory evidence of immunity.


Methodology

See individual tests.


Reference Interval

See individual tests.


Additional Information

Measles

Acceptable presumptive evidence of Measles Immunity (at least one of the following):

• Documentation of age-appropriate vaccination against measles virus.

• Laboratory evidence of immunity (IgG in serum; equivocal results should be considered negative).

• Laboratory confirmation of measles.

• Birth before 1957.

Persons who have measles-specific IgG antibody that is detectable by any commonly used serological assay are considered to have adequate laboratory evidence of measles immunity. Persons with an equivocal serologic test result do not have adequate presumptive evidence of immunity and should be considered susceptible unless they have other evidence of measles immunity.

Documented age-appropriate vaccination supersedes the results of subsequent serologic testing. If a person who has two documented doses of measles-containing vaccine is tested serologically and is determined to have negative or equivocal measles results, it is not recommended that the person receive an additional dose of vaccine. Such persons should be considered to have presumptive evidence of immunity.

Mumps

Acceptable presumptive evidence of Mumps Immunity (at least one of the following):

• Documentation of age-appropriate vaccination against mumps virus.

• Laboratory evidence of immunity (IgG in serum; equivocal results should be considered negative).

• Laboratory confirmation of disease.

• Born before 1957.

Rubella

Acceptable presumptive evidence of Rubella Immunity (at least one of the following):

• Documentation of 1-dose of live rubela virus-containing vaccine.

• Laboratory evidence of immunity (IgG in serum; equivocal results should be considered negative).

• Laboratory confirmation of disease.

• Born before 1957 (except women of childbearing age who could become pregnant).


References

Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases. CDC web site. https://www.cdc.gov/vaccines/pubs/surv-manual/index.html. Accessed June 2019.
Centers for DIsease Control and Prevention. Measles (Rubeola): For Healthcare Professionals. CDC web site. https://www.cdc.gov/measles/hcp/. Accessed June 2019.
McLean HQ, Fiebelkorn AP, Temte JL, Wallace GS; Centers for Disease Control and Prevention. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2013 Jun 14;62(RR-04):1-34.23760231

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
058495 Measles/Mumps/Rubella Immunity 006204 Rubella Antibodies, IgG index 5334-8
058495 Measles/Mumps/Rubella Immunity 096564 Rubeola Ab, IgG AU/mL 5244-9
058495 Measles/Mumps/Rubella Immunity 096554 Mumps Abs, IgG AU/mL 25418-5

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf