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- LKM-1 Antibodies
The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease. The disease is most common between the ages of 2 to 14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.
A negative LKM-1 result does not rule out the presence of autoimmune hepatitis type 2. LKM-1 may be detected in some patients as a result of HCV infection and may not be the result of AIH-2.
Enzyme-linked immunosorbent assay (ELISA)
• Negative: 0.0−20.0
• Equivocal: 20.1−24.9
• Positive: >24.9
To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|163980||Liver-Kidney Microsomal Ab||32220-6||163982||Liver-Kidney Microsomal Ab||Units||32220-6|