Iodine, 24-Hour Urine

CPT: 83789
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Special Instructions

If 24-hour urine is submitted, the test request form must state 24-hour collection volume.


Expected Turnaround Time

3 - 5 days


Specimen Requirements


Specimen

Urine (24-hour)


Volume

5 mL


Minimum Volume

2 mL


Container

Plastic urine container, no preservative


Collection

Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely. Transport the specimen promptly to the laboratory. Container must be labeled with the patient's full name, room number, the date and time collection started, and the date and time collection finished. Do not use preservative.


Storage Instructions

Maintain specimen at room temperature.


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Test Details


Use

Monitor exposure to iodine; evaluate for iodine deficiency disorders (IDDs), excessive iodine intake, or iodine in the workplace

IDDS by Age Group

Age Groups

Health Consequences of Iodine Deficiency

Zimmerman MB, "Iodine Deficiency," Endocrine Reviews, The Endocrine Society, 2009, 30:376-408.

All ages

Goiter

Increased susceptibility of thyroid gland to nuclear radiation

Fetus

Abortion

Stillbirth

Congenital anomalies

Perinatal mortality

Neonates

Infant mortality

Endemic cretinism

Children and adolescents

Impaired mental function

Delayed physical development

Adults

Impaired mental function

Reduced work productivity

Toxic nodular goiter; iodine-induced hyperthyroidism

Increased occurrence of hypothyroidism in moderate-to-severe iodine deficiency; decreased occurrence of hypothyroidism in mild-to-moderate iodine deficiency

Other forms of thyroid problems, namely iodine-induced hypothyroidism, autoimmune thyroiditis, and hyperthyroidism associated with excessive iodine intake, have become a greater concern than deficiency disorders.1


Methodology

Inductively-coupled plasma/mass spectrometry (ICP/MS)


Reference Interval

100.0−460.0 μg/24 hours


Footnotes

1. Hollowell JG, Staehling NW, Hannon WH, et al. Iodine nutrition in the United States, trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab. 1998; 83(10):3401-3408.9768638

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070222 Iodine, 24 Hr Urine 2492-7 070164 Iodine, Urine ug/L 2495-0
070222 Iodine, 24 Hr Urine 2492-7 070223 Iodine, 24 Hr Urine ug/24 hr 2492-7

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