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Fluorescence in situ Hybridization (FISH), Paraffin Block
- Cytogenetics Fluorescence in situ Hybridization on Paraffin-embedded Tissue
For specific FISH probe analysis of tissue specimens
Samples in formaldehyde greater than 12 hours may reduce hybridization efficiency.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.
Fluorescence in situ hybridization (FISH) from formalin-fixed tissue-embedded paraffin (4-micron to 5-micron sections); H&E for pathology review.
Formalin/bone marrow-fixed (not decalcified); paraffin-embedded tissue or six 4-micron to 5-micron thick section slides
One paraffin block or six 4-micron to 5-micron thick section slides
Partial paraffin block to make several slides/probe
Specimen should be fixed in 10% neutral-buffered formalin or formaldehyde.
Maintain specimen at room temperature.
Causes for Rejection
Improperly embedded prep; poor fixation <6 hours and >72 hours; decalcified bone or bone core; broken or dirty slides; absence of tumor or quantity not sufficient for analysis
This test number is used for tracking FISH paraffin samples to the testing facility. Billing will occur after testing is completed.
Pertinent medical findings and probe desired must accompany request for FISH. If prior chromosome analysis has been performed, include a copy of the report. Please direct questions to genetics customer service at 800-345-4363.