Fluorescence in situ Hybridization (FISH), Oncology

CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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Test Details

Use

Confirmation/identification of leukemia/lymphoma-related alterations; leukemia/lymphoma monitoring of residual disease, transplants, and indolent clones (see list or call lab for probe availability).

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA are also acceptable.

Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

Container

Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Collection

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow the sample to freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; frozen specimen

Clinical Information

Special Instructions

Call for additional probes not listed above. Pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest should be included with the specimen (Call for a list of available probes or see online list.).

This test number is used for tracking oncology FISH specimens to the laboratory. Bill codes will be added when testing is complete, based on the processes performed in the laboratory.

Please provide targeted FISH probe and diagnosis. This test is essentially a tracking code, and the test will only be performed after the probes and diagnosis is provided. Absence of this information will delay turnaround time.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510669 FISH Oncology 510670 Specimen Type 31208-2
510669 FISH Oncology 510671 Cells Counted 62361-1
510669 FISH Oncology 510672 Cells Analyzed 62360-3
510669 FISH Oncology 510673 FISH Result 62356-1
510669 FISH Oncology 510674 Interpretation 62365-2
510669 FISH Oncology 510638 Director Review: 48672-0

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf