Creatine

CPT: 82540
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Special Instructions

State the patient's sex on the test request form.


Expected Turnaround Time

3 - 6 days


Related Documents


Specimen Requirements


Specimen

Serum, frozen


Volume

1 mL


Minimum Volume

0.5 mL


Container

Red-top tube


Collection

Separate serum from red cells. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Freeze


Causes for Rejection

Hemolysis; specimen not frozen


Test Details


Use

Serum creatine levels may be significantly increased in amyotrophic lateral sclerosis, dermatomyositis, myasthenia gravis, starvation, muscular dystrophies, and trauma. Creatine synthesis is stimulated by methyltestosterone and may also be increased in hyperthyroidism, diabetic acidosis, and puerperium.


Methodology

Enzymatic (creatinase)/spectrophotometry


Reference Interval

See table.

Age (y)

Range (mg/dL)

0−1

0.1−1.4

2−5

0.6−1.4

6−9

0.5−1.3

10−13

0.2−1.1

14−17

0.0−0.8

Female: >17

0.1−1.0

Male: >17

0.0−0.7


Additional Information

Creatine is transported from the sites of synthesis (kidney, liver, pancreas) via the circulatory system to muscle and brain tissue where it is phosphorylated to phosphocreatine. Phosphocreatine and creatine are rapidly interconverted during muscle contraction. Approximately 1% to 2% of free creatine in muscle is converted to creatinine daily.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
002402 Creatine, Serum 2148-5 002402 Creatine, Serum mg/dL 2148-5

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