Creatine

CPT: 82540
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Test Details

Use

Serum creatine levels may be significantly increased in amyotrophic lateral sclerosis, dermatomyositis, myasthenia gravis, starvation, muscular dystrophies, and trauma. Creatine synthesis is stimulated by methyltestosterone and may also be increased in hyperthyroidism, diabetic acidosis, and puerperium.

Methodology

Enzymatic (creatinase)/spectrophotometry

Reference Interval

See table.

Age (y)

Range (mg/dL)

0−1

0.1−1.4

2−5

0.6−1.4

6−9

0.5−1.3

10−13

0.2−1.1

14−17

0.0−0.8

Female: >17

0.1−1.0

Male: >17

0.0−0.7

Additional Information

Creatine is transported from the sites of synthesis (kidney, liver, pancreas) via the circulatory system to muscle and brain tissue where it is phosphorylated to phosphocreatine. Phosphocreatine and creatine are rapidly interconverted during muscle contraction. Approximately 1% to 2% of free creatine in muscle is converted to creatinine daily.

Specimen Requirements

Specimen

Serum, frozen

Volume

1 mL

Minimum Volume

0.5 mL

Container

Red-top tube

Collection

Separate serum from red cells. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze

Causes for Rejection

Hemolysis; specimen not frozen

Clinical Information

Special Instructions

State the patient's sex on the test request form.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
002402 Creatine, Serum 2148-5 002402 Creatine, Serum mg/dL 2148-5

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf