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- Antibiotic-associated Colitis Toxin Test
- Pseudomembranous Colitis Toxin Assay
Aid in the diagnosis of antibiotic-associated diarrheal disease and pseudomembranous colitis
Detection of toxins A and B by enzyme immunoassay has a sensitivity approaching 90%, so multiple specimens may need to be tested. Performance characteristics have not been established for patients less than two years of age.
Enzyme immunoassay (EIA) for Clostridium difficile toxins A and B
C difficile can produce two toxins, designated A and B, that have pathogenic effects in humans. Antibiotic-associated pseudomembranous colitis has been shown to result from the action of these two toxins. This disease has been associated with clindamycin use but it is now recognized that pseudomembranous colitis can follow administration of virtually any antibiotic. More than 70% of the cases in a large series were associated with cephalosporin therapy.1 The clinical spectrum of antibiotic-induced syndromes caused by C difficile includes patients with symptoms of acute abdomen with little or no diarrhea, as well as cases with fulminant life-threatening diarrhea. Nosocomial transmission and reinfection with different strains occurs as do spontaneous cases without prior antimicrobial therapy. In cases where cessation of antibiotic therapy does not produce a response, specific therapy with oral vancomycin, metronidazole, or oral bacitracin may be effective. Detection of the toxins produced by C difficile (rather than culture of the organism) is important in the determining therapy of this potentially fatal disease. The routine use of culture does not seem appropriate because of the costs and the high rate of recovery of strains which do not produce toxin.
0.5 g or 0.5 mL liquid stool
Causes for Rejection
A separate specimen is required for culture or for the toxin B cytotoxin assay.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|086207||C difficile Toxins A+B, EIA||34468-9||182238||C difficile Toxins A+B, EIA||34468-9|