CHOP Oncology FISH

CPT: 88271(x2); 88275
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Test Details


  • Leukemia FISH
  • Lymphoma FISH


Confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas)


Fluorescence in situ hybridization (FISH)

Additional Information

The CHOP break-apart FISH probe is designed to rule out a rearrangement of the gene located at 12q13 associated with a reciprocal (12;16)(q13;p11) translocation (CHOP-TLS gene fusion) and myxoid/round cell liposarcoma. CHOP is fused to TLS in about 90% of myxoid liposarcomas/round cell liposarcomas.

Specimen Requirements


Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.


Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow


Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Clinical Information

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510349 CHOP Oncology FISH 510351 FISH Result 48674-6
510349 CHOP Oncology FISH 510352 Director Review: 48672-0
510349 CHOP Oncology FISH 510520 Specimen Type 31208-2
510349 CHOP Oncology FISH 510521 Cells Counted N/A
510349 CHOP Oncology FISH 510522 Cells Analyzed N/A
510349 CHOP Oncology FISH 510526 Interpretation 50398-7
510349 CHOP Oncology FISH 511936 PDF 80563-0

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