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- Leukemia FISH
- Lymphoma FISH
Confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas)
Fluorescence in situ hybridization (FISH)
The CHOP break-apart FISH probe is designed to rule out a rearrangement of the gene located at 12q13 associated with a reciprocal (12;16)(q13;p11) translocation (CHOP-TLS gene fusion) and myxoid/round cell liposarcoma. CHOP is fused to TLS in about 90% of myxoid liposarcomas/round cell liposarcomas.
Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.
Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow
Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow
Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.
Maintain specimen at room temperature.
Causes for Rejection
Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen
There will be an additional charge for processing paraffin block samples or for samples that require culture.