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- No Doz® Maximum Strength
Monitor caffeine concentration in newborns receiving theophylline or caffeine.
Half-life elimination: Neonates 72 to 96 hours, Children >9 months and Adults: 5 hours
Time to peak serum, oral: Within 30 minutes to 2 hours
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
• Therapeutic: 3.0−15.0 μg/mL
• Neonatal apnea: 8−14 μg/mL
• Infant (<1 year): 8−20 μg/mL
Theophylline is used to treat neonatal apnea. Unlike its metabolism in adults, theophylline in neonates is extensively metabolized to caffeine. Plasma elimination half-life in adults is three to six hours. In neonates, caffeine has a half-life of 30 hours. Caffeine overdoses are rare. The clinical presentation is similar to that of theophylline.
Serum or plasma
Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
Transfer separated serum or plasma to a plastic transport tube.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|071258||Caffeine, Serum||3422-3||071262||Caffeine, Serum||ug/mL||3422-3|