Breast Cancer Prognosis Profile II, Paraffin Block

CPT: 88360(x2); 88377
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Test Details

Test Includes

Estrogen/progesterone receptor (ER/PR) assay; HER-2/CEP17 FISH assay


Provide prognostic information to aid the physician in determining risk of recurrence and potential benefits of therapy options for the breast cancer patient; HER-2/neu gene amplification status is a predictor of response to certain breast cancer treatments, including targeted immunotherapy.


Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results.


ER/PR: immunohistochemistry; HER-2/neu gene amplification status: fluorescence in situ hybridization (FISH)

Specimen Requirements


Formalin-fixed, paraffin-embedded (FFPE) tumor


One paraffin block


Paraffin block transport pouch


Specimen should be fixed in 10% neutral-buffered formalin. Optimum fixation time is 12 to 24 hours, not to exceed 48 hours.

Storage Instructions

Maintain specimen at room temperature.

Clinical Information

Special Instructions

Please direct any questions regarding this test to oncology customer service at 800-345-4363.

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CPT Statement/Profile Statement

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