Find Locations
For hours, walk-ins and appointments.Breast Cancer Prognosis Profile II, Paraffin Block
CPT:
88360(x2); 88377
Test Includes
Estrogen/progesterone receptor (ER/PR) assay; HER-2/CEP17 FISH assay
Special Instructions
Please direct any questions regarding this test to oncology customer service at 800-345-4363.
Expected Turnaround Time
5 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Formalin-fixed, paraffin-embedded (FFPE) tumor
Volume
One paraffin block
Container
Paraffin block transport pouch
Collection
Specimen should be fixed in 10% neutral-buffered formalin. Optimum fixation time is 12 to 24 hours, not to exceed 48 hours.
Storage Instructions
Maintain specimen at room temperature.
Test Details
Use
Provide prognostic information to aid the physician in determining risk of recurrence and potential benefits of therapy options for the breast cancer patient; HER-2/neu gene amplification status is a predictor of response to certain breast cancer treatments, including targeted immunotherapy.
Limitations
Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results.
Methodology
ER/PR: immunohistochemistry; HER-2/neu gene amplification status: fluorescence in situ hybridization (FISH)
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 480278 | Estrogen Receptor IHC | % | 14228-1 |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 480279 | Progesterone Rec. IHC | % | 14230-7 |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 480276 | Comment | 8251-1 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 480268 | Fixative | N/A | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 480299 | Fixation Time | N/A | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 480298 | Additional Information | 19147-8 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483249 | HER-2/neu FISH | 31150-6 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483299 | HER-2/CEP17 Ratio | 49683-6 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483328 | Avg Num Her-2 signals/nucleus: | 74860-8 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483329 | Avg Num CEP17 probes/nucleus: | 74861-6 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483332 | Number of Tumor Cells Counted: | 62361-1 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483334 | Number of Observers: | N/A | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483259 | Fixation Time | N/A | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483260 | Fixative | N/A | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483336 | Scoring Criteria | 19147-8 | |
| 495036 | Breast Ca Prog II, Paraffin | 74885-5 | 483002 | Director Review | N/A |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf