Anti-DNase B (Streptococcal) Antibodies

CPT: 86215
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Synonyms

  • ADB
  • Anti-DNase B Antibodies
  • DNase-B
  • DNase-B Antibodies
  • Streptococcal Antibodies
  • Streptodornase

Expected Turnaround Time

3 - 5 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Maintain specimen at room temperature.


Stability Requirements

Temperature

Period

Room temperature

9 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Gross lipemia that cannot be clarified by ultracentrifugation; heat-inactivated samples; severe hemolysis


Test Details


Use

Provides evidence of an existing or past streptococcal infection


Methodology

Immunonephelometry


Reference Interval

• <1 year: not established

• 1 to 6 years: <78 U/mL

• 7 to 17 years: ≤170 U/mL

• 18 years and older: ≤120 U/mL


Additional Information

ADNase B antibodies react against the exoenzyme desoxyribonuclease B produced by streptococci. The detection of these antibodies provides evidence of an existing or past streptococcal infection (rheumatic fever, scarlet fever, tonsillitis, glomerulonephritis, and others). The antibody reaction against streptococcal DNase B starts later than the antibody production against streptolysin O, but it can then be detected on a greater percentage of patients.1 An increase in the antistreptolysin concentration rarely occurs with skin infections, while a rise in the ADNase B titer can be observed.1-3


Footnotes

1. Hederstedt B, Holm SE, Wadström T. Antibodies after B-Streptococcal infections. In: Medical Laboratory. Marburg, Germany: Behringwerke AG;1979: 7:24-28.
2. Dillon HC Jr, Reeves MS. Streptococcal immune responses in nephritis after skin infections. Am J Med. 1974 Mar; 56(3):333-346. 4813651
3. Kaplan EL, Anthony BF, Chapman SS, Ayoub EM, Wannamaker LW. The influence of the site of infection on the immune response to group A streptococci. J Clin Invest. 1970 Jul; 49(7):1405-1414. 5432372

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
096289 Anti-DNase B Strep Antibodies 5133-4 123904 Anti-DNase B Strep Antibodies U/mL 5133-4

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