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In Vitro Safety Assessment for Chemical Products

Faster, more confident chemical safety decisions—with human relevant NAMs built for today’s regulatory expectations
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Navigate chemical safety requirements with clarity and confidence

As global regulatory agencies accelerate the shift toward New Approach Methods (NAMs) and reduce reliance on vertebrate testing—driven by TSCA mandates and EPA’s NAM Strategic Plan—chemical developers need human‑relevant, mechanistically rich data earlier in development. Labcorp helps you meet these expectations with in vitro strategies designed for clarity, regulatory alignment, and confident decision‑making.

Navigate Chemical Safety Requirements With Confidence

With more than 20 years of in vitro toxicology expertise, Labcorp delivers modern NAM technologies and proven scientific depth to help developers:

  • Reduce uncertainty early

  • Support regulatory acceptance

  • Generate evidence suitable for TSCA, REACH, ECHA and global submissions


Our in vitro portfolio is built for efficiency, mechanistic insight, and alignment with the evolving expectations of global authorities.

NAM-driven in vitro testing built around your goals

Whether you're refining a screening funnel, preparing a weight-of-evidence package, or responding to regulatory requests, you get fit-for-purpose study designs aligned to your chemical’s properties and program stage. 

Labcorp helps you:

  • Identify the right NAMs for your hazard profile
  • Generate mechanistic insight regulators value
  • Build submissions that anticipate scientific and regulatory scrutiny

Featured in vitro assays for deeper mechanistic clarity

Below are two of our most advanced human‑cell–based NAMs—each offering powerful, mechanism‑informed insight early in your safety program.

ToxTracker®
 

A validated stem‑cell–based reporter assay for genotoxicity mechanism identification

ToxTracker detects DNA damage and activation of stress response pathways, distinguishing:
 

  • Direct DNA reactivity
  • Oxidative stress
  • Protein damage
  • Other indirect mechanisms.

This mechanistic resolution helps reduce regulatory challenges by clearly explaining why and how a compound triggers genotoxic effects.

devTOX quickPredict™ 


A human-cell–based developmental toxicity NAM—NEW

devTOX quickPredict gives you early, exposure-based insight into developmental toxicity potential before initiating in vivo work. It supports:
 

  • Earlier hazard screening,
  • Prioritization of safer candidates,
  • More strategic dose selection,
  • Stronger weight-of-evidence arguments, and of evidence arguments, and
  • Alignment with 3Rs and global NAM expectations.

Together, ToxTracker and devTOX quickPredict deliver complementary insight across genotoxicity and developmental toxicity—
supporting smarter, earlier decisions for your crop protection program.

Comprehensive in vitro safety capabilities—aligned with global chemical standards

As chemical regulations expand and toxicology science evolves, you need more than a list of assays—you need a partner who understands how each method supports your regulatory strategy.

Our in vitro portfolio includes:

  • Genotoxicity and Carcinogenicity (e.g., ToxTracker®, Ames, IVMN, and CTA)

  • Endocrine activity assays

  • Cytotoxicity and phototoxicity
     

  • Mechanistic/mode of action evaluations

  • Sensitization and irritation studies

  • 3D tissue models and NAM‑aligned systems

Frequently asked questions