Modelling neurodegeneration with 3D bio-printed iPSC-derived neural models

MPS World Summit 2026 -- On an individual and societal level, neurodegenerative diseases represent a major health burden. Global projections estimate over 150 million cases of Alzheimer’s disease by 2050. Current neurotoxicity safety assessment is reliant on in vivo models, which are time-consuming, may not accurately represent human biology and have documented translational limitations. Each of these problems can be addressed by in vitro models. Here we leverage innovative 3D bio-printing approaches and have developed a 3D bio-printed, isogenic, tri-lineage induced pluripotent stem cell (iPSC)-derived neural organoid model, displaying key architecture consistent with human neural structure and function. We provide a proof-of-concept dataset that demonstrates the model’s utility for the assessment of neurodegenerative effects following exposure to a broad range of stressors (including endogenous pathological associated peptides, inflammatory agents, phosphatase inhibitors, nanomaterials and metal compounds, agrochemical and chemical agents). Following a differentiation and growth phase of 6 months, 3D bio-printed iPSC-derived neural models were exposed to stressors on six occasions over a 2-week period. Endpoints for viability, gene expression, CNS deposition, oxidative stress and cytokine release were performed and demonstrate the model’s utility in assessment of neurodegenerative risk.