Oral Fluid Drug Testing

Convenient Collection

LabCorp's oral fluid drug testing program provides a simple method to collect chain of custody drug screen specimens almost anywhere. The oral fluid collection is directly observed, making it less susceptible to specimen adulteration.1 The donor simply opens the sealed collection device, places it in his or her mouth, and the collector transfers the specimen into the transport tube for shipment to the laboratory.

Sensitive Testing

Because oral fluid specimens require much lower screening levels than urine, LabCorp performs the initial screening test by enzyme-linked immunosorbent assay (ELISA) microplate technology. ELISA is one of the current screening methods with adequate sensitivity to detect drugs of abuse in oral fluid specimens.1 LabCorp offers mass spectrometry confirmation of presumptive positive screens.

Our oral fluid drug test profile contains: 

  • Amphetamine/methamphetamine/ecstasy
  • Barbiturates
  • Benzodiazepines
  • Cannabinoid (THC)
  • Cocaine
  • Ethyl Alcohol
  • Opiates (codeine, morphine, 6-acetylmorphine)
  • Phencyclidine (PCP)
  • Propoxyphene

Results for specimens that screen negative for all drugs are generally available within 24 hours after specimens are received at the laboratory. Results for confirmation testing of presumptive positive screens are usually available within an additional 72 hours.

To set up an oral fluid drug testing program, contact LabCorp sales.

Oral Fluid Drug Testing FAQ

Drug detection times vary depending on the dose, sensitivity of the testing method used, preparation and route of administration, duration of use (acute or chronic), the matrix that is analyzed, the molecule or metabolite that is looked for, the pH and concentration of the matrix (urine, oral fluid), and variations in metabolic and renal clearance. In general, the detection time is longest in hair, followed by urine and oral fluid. Drugs in hair may be detectable for up to 90 days, whereas drugs in urine are generally detectable for one to seven days (or longer in chronic users) and in oral fluid from five to 48 hours.2

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Yes. For this reason, the donor is to refrain from consumption of food or beverages for 10 minutes prior to specimen collection.1

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The buffer solution is used to inhibit bacterial growth.

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Depending on the drug used, dose, and route of administration, a drug may be detected in oral fluid in less than one hour and remain detectable for five up to 48 hours after last use.1,2

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