The devTOX quickPredict™ assay: Blinded study demonstrates high inter-laboratory reproducibility for in vitro developmental toxicity NAM

ESTIV Congress 2026 -- Traditional animal-based developmental toxicity tests are slow, costly, and may not reflect human biology. devTOX quickPredict™ is a fast, low‑cost, human in vitro assay using human induced pluripotent cells (hiPSCs) and metabolomic biomarkers. It predicts potential developmental toxicities by tracking changes in ornithine/cystine ratios across a dose‑response curve. A compound’s developmental toxicity potential (dTP) is defined by when this ratio crosses a developmental toxicity threshold (dTT). The method can detect toxicity at non‑cytotoxic doses, reducing false signals from cell death. Undifferentiated hiPSCs enhance relevance to early human development.