Based in Geneva, Dr. Nicolas Anfossi is Senior Director, Laboratory Operations at Labcorp, CLS, he joined since mid-2018. On his current role, Nicolas oversees the global operations of Flow Cytometry department (5 sites worldwide) to ensure generation of reliable flow cytometry data, while keeping compliant with stringent regulations.
He has 20 years of experience in the pharmaceutical industry across preclinical and clinical drug development, with strong background with immunotherapies, 15 years of which as service provider for flow cytometry and immuno-assays, mainly in the field of oncology, infectious, inflammatory and neurodegenerative diseases.
Nicolas had authored dozens of peer-reviewed publications, including book chapters, and contributed to many posters and presentations. He received is Ph.D in immunology in 2004 from University Aix-Marseille, France, and holds a Master in general business administration since 2014 from Business administration Institute, Lyon, France.
Area of Expertise: Flow Cytometry
Publications:
- Cognet C, Farnarier C, Gauthier L, Frassati C, André P, Magérus-Chatinet A, Anfossi N, Rieux-Laucat F, Vivier E, Schleinitz N.
Expression of the HLA-C2-specific activating killer-cell Ig-like receptor KIR2DS1 on NK and T cells.
Clin Immunol. 2010. 135:26-32. - Romagné F, André P, Spee P, Zahn S, Anfossi N, Gauthier L, Capanni M, Ruggeri L, Benson DM Jr, Blaser BW, Della Chiesa M, Moretta A, Vivier E, Caligiuri MA, Velardi A, Wagtmann N.
Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells.
Blood. 2009. 114:2667-77. - André P. and N. Anfossi.
Clinical analysis of human natural killer cells.
Methods in molecular biology. 2008. 415: 291-300 - Anfossi N., André P., Guia S., Falk C., Roetynck S., Stewart C., Breso V., Frassati C., Reviron D., Middleton D., Romagné F., Ugolini S. and E. Vivier.
Human NK cell education by inhibitory receptors for MHC class I.
Immunity. 2006. 25: 331-342 - Anfossi N., Doisne JM., Bonnaud O., Ugolini S., Bossy D., Dechanet-Merville J., Bonneville M., Venet A., and E. Vivier.
Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells.
The journal of Immunology. 2004. 173: 7223-7229 - Anfossi N., Robbins S., Ugolini S., Georgel P., Hoebe K., Bouneaud C., Ronet C., Kaser A., DiCioccio C., Tomasello E., Blumberg R., Beutler B., Reiner S., Alexopoulou L., Lantz O., Raulet D., Brossay L. and E. Vivier.
Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules.
The journal of Immunology. 2004. 173: 3773-3782 - André P., Castriconi R., Espéli M., Anfossi N., Juarez T., Hue S., Conway H., Romagné F., Dondero A., Nanni M., Caillat S., Raulet D., Bottino C., Vivier E., and Moretta A. and P. Paul.
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.
European journal of Immunology. 2004. 34: 961-971. - Vivier E. and N. Anfossi.
Inhibitory NK cell receptors on CD8+ T cells: witness of the past, actors of the future.
Nature Reviews Immunology. 2004. 4: 190-198. - Anfossi, N., Lucas, M., Diefenbach, A., Bühring HJ., Raulet, D., Tomasello E. and E. Vivier.
Contrasting roles of DAP10 and KARAP/DAP12 signaling adaptors in activation of the RBL-2H3 leukemic mast cell line.
European Journal of Immunology. 2003. 33: 3514-3522. - Ugolini, S., Arpin, C., Anfossi, N., Walzer, T., Cambiaggi, A., Förster, R., Lipp, M., Toes, R., Melief, C., Marvel, J. and E. Vivier.
Involvment of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.
Nature Immunology. 2001. 2 (5): 430-435. - Anfossi, N., Pascal, V., Vivier, E. and S. Ugolini.
Biology of Tm1 cells.
Immunological reviews. 2001. 181: 269-278. - Anfossi, N., Pascal, V., Ugolini, S. and E. Vivier.
Characterization of Tm1 cells, a NKR+ subset of memory-phenotype CD8+ T cells.
In CREST book "Activating and Inhibitory Immunoglobulin-like Receptors". 2001. Editors: Cooper, M.D, Takai, T. and J.V. Ravetch.