Sex Hormone Binding Globulin, Serum
| Sex Hormone Binding Globulin, Serum | | | |
| Number | | 082016 |
| CPT | | 84270 |
| Synonyms | | SHBG ; TeBG ; Testosterone Binding Globulin |
| Special Instructions | | Specify sex and age of patient on the request form. |
| Specimen | | Serum |
| Volume | | 0.5 mL |
| Minimum Volume | | 0.3 mL (Note: This volume does not allow for repeat testing.) |
| Container | | Red-top tube or gel-barrier tube |
| Collection | | If a red-top tube is used, transfer separated serum to a plastic transport tube. |
| Storage Instructions | | Refrigerate |
| Causes for Rejection | | Plasma specimen |
| Reference Interval | | See table.1
| Age | Male
(nmol/L) | Female
(nmol/L) | | 0-1 mo | 11-71 | 12-51 | | 1-12 mo | 60-209 | 50-181 | | 1-3 y | 42-156 | 51-158 | | 4-6 y | 39-146 | 48-142 | | 7-9 y | 38-114 | 31-103 | | 10-12 y | 32-93 | 20-100 | | 13-15 y | 13-93 | 17-77 | | 16-18 y | 11-54 | 9-75 | | >18 y | 13-71 | 18-114 |
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| Use | | Levels of SHBG are under the positive control of estrogens and thyroid hormones, and are suppressed by androgens. These influences dynamically control the liver synthesis of this carrier protein. Decreased levels of SHBG are frequently seen in hirsutism, virilization, obese postmenopausal women, and in women with diffuse hair loss. Increased levels may be present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children. |
| Methodology | | Immunochemiluminometric assay (ICMA) |
| Footnotes | | - Hicks SJ, Bailey JM, Beatey J, et al, “Pediatric Reference Ranges for Sex Hormone Binding Globulin,” Clin Chem, 1997, 43:S200
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| References | | Andreyko JL, Bhavnani BR, Nisker JA, et al, “Role of Serum Androgens and Sex Hormone Binding Globulin Capacity in the Evaluation of Hirsutism in Women,” Clin Biochem, 1986, 19(1):58-61. Cunningham SK, Loughlin T, Culliton M, et al, “Plasma Sex Hormone-Binding Globulin and Androgen Levels in the Management of Hirsute Patients,” Acta Endocrinol (Copenh), 1983, 104(3):365-71. Maruyama Y, Aoki N, Suzuki Y, et al, “Sex-Steroid-Binding Plasma Protein (SBP), Testosterone, Oestradiol, and Dehydroepiandrosterone (DHEA) in Prepuberty and Puberty,” Acta Endocrinol (Copenh), 1987, 114(1):60-7. |
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