Porphobilinogen (PBG), Quantitative, Random Urine
| Porphobilinogen (PBG), Quantitative, Random Urine | | | |
| Number | | 003053 |
| CPT | | 84110 |
| Related Information | | Porphobilinogen (PBG), Quantitative, 24-Hour Urine Urine Testing: Preservative Quick Reference Chart |
| Synonyms | | PBG Random Urine, Quantitative |
| Special Instructions | | Use test 003103 for 24-hour urine. |
| Specimen | | Urine (random), frozen and protected from light |
| Volume | | 10 mL |
| Minimum Volume | | 1 mL |
| Container | | Plastic urine container with 0.5 mL of 30% glacial acetic acid. Use amber plastic urine cup and amber top; order LabCorp No 20656. (If amber cups are unavailable, cover plastic container completely, top and bottom, with aluminum foil. Identify specimen with patient name directly on the container and on the outside of the aluminum foil. Secure with tape.) |
| Collection | | Acidify sample with 0.5 mL 30% glacial acetic acid. Freeze. Protect from light. |
| Storage Instructions | | Freeze immediately and protect from light. Urine is stable when preserved with sodium carbonate to pH of 8 and frozen for up to 8 months and when refrigerated for up to 72 hours. Stable when preserved with 30% glacial acetic acid and frozen for up to 1 month or when refrigerated for up to 24 hours. |
| Causes for Rejection | | Specimen exposed to light; specimen not received frozen; improper or no preservative |
| Reference Interval | | 0.0-2.0 mg/L |
| Use | | Detect porphyrias and porphyrinurias. Acute intermittent porphyria is characterized by excretion of porphobilinogen and delta aminolevulinic acid in urine during acute attacks, but not during latency. Increased porphobilinogen may be caused also by variegate porphyria or hereditary coproporphyria. Increased urine values are seen in the intoxication porphyrias (heavy metals, halogenated solvents, certain drugs). |
| Limitations | | A 24-hour urine collection (see Porphobilinogen (PBG), Quantitative, 24-Hour Urine [003103] ) may provide more clinically representative data. |
| Methodology | | Chromatography/spectrophotometry |
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