Integrated 2
Integrated 2  | | | |
| Number | | 017170 |
| CPT | | 82105 ; 82677 ; 84702 ; 86336 |
| Related Information | | Integrated 1 (017100) |
| Synonyms | | AFP ; Maternal ; Down Syndrome |
| Special Instructions | | Test inquiries call CMBP Genetic Services at 800-345-GENE.
Patient must have submitted a previous specimen in the
first trimester for the Integrated 1 test. Gestational age
will be based on crown rump length provided with the first
trimester specimen. Patient information may be provided to
the laboratory using the Maternal Prenatal Screening
requisition 0900. Testing provided from 15.0 to 21.9 weeks
gestation. |
| Specimen | | Serum |
| Volume | | 5 mL |
| Minimum Volume | | 3 mL |
| Container | | Gel-barrier tube, no thrombin additive |
| Collection | | Avoid hemolysis; send complete specimen in the original
tube. Do not pour off. |
| Storage Instructions | | Refrigerate |
| Causes for Rejection | | Gross hemolysis; gross lipemia; quantity not sufficient for
analysis; improper specimen type |
| Use | | Screening test for open neural tube defects, Down Syndrome,
and Trisomy 18. |
| Limitations | | Integrated screening requires two specimens: one collected
in the first trimester and one in the second trimester.
This test number is for the second trimester portion of the
test. This is a screening test. A positive result means
that diagnostic testing may be offered to the pregnant
woman to determine if a neural tube defect or chromosome
abnormality is present. |
| Methodology | | AFP, uE3, and hCG by chemiluminescent immunoassay; DIA by
enzyme immunoassay (EIA) |
| References | | Wald NJ, Watt HC, Hackshaw AK.
Integrated Screening for Down's Syndrome Based on Tests
Performed During the First and Second Trimesters. New
Eng. J. Med, 1999; 341(7): 461-467. |
|