p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block
| p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block | | | |
| Number | | 481044 |
| CPT | | 88360 |
| Synonyms | | Tumor Suppressor Gene, p53 |
| Special Instructions | | Please direct any questions regarding this test to Oncology Customer Service at 800-533-0567. |
| Specimen | | Tumor (formalin-fixed, paraffin-embedded) |
| Volume | | One paraffin block |
| Container | | Paraffin block transport pouch |
| Collection | | Specimen should be fixed in 10% neutral-buffered formalin. Optimum fixation time is 12-24 hours, not to exceed 48 hours. |
| Storage Instructions | | Maintain specimen at room temperature. |
| Use | | Alterations of the p53 tumor suppressor gene have been shown to serve as a powerful independent prognostic marker in a wide variety of tumor types such as colorectal,1,2 breast,3,4 prostate,5 and bladder.6 Multiple studies have supported the observation of alterations of p53 leading to tumor recurrence and shorter disease-free survival.7 |
| Limitations | | This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients. |
| Methodology | | Immunohistochemistry (IHC) |
Footnotes | | - Yamaguchi A, Kurosaka Y,
Fushida S. et al. “Expression of p53 Protein in Colorectal
Cancer and its Relationship to Short-Term Prognosis,”
Cancer, 1992; 70(12):2778-2784.
- Starzynska T, Bromley M, Ghosh A. et
al. “Prognostic Significance of p53 Overexpression in
Gastric and Colorectal Carcinoma”, Br J Cancer,
1992; 66(3):558-562.
- Allred DC, Clark GM, Elledge R. et
al. “Association of p53 Protein Expression With Tumor Cell
Proliferation Rate and Clinical Outcome in Node-Negative
Breast Cancer,” J Natl Cancer Inst, 1993;
85(3):200-206.
- Thor AD, Moore DH II, Edgerton SM. et
al. “Accumulation of p53 Tumor Suppressor Gene Protein: An
Independent Marker of Prognosis in Breast Cancers,” J
Natl Cancer Inst, 1992; 84(11):845-855.
- Visakorpi T, Kallioniemi OP, Heikkinen A. et
al. “Small Subgroup of Aggressive, Highly Proliferative
Prostatic Carcinomas Defined by p53 Accumulation,” J
Natl Cancer Inst, 1992; 84(11):883-887.
- Sarkis AS, Dalbagni G, Cordon-Cardo C. et
al. “Nuclear Overexpression of p53 Protein in Transitional
Cell Bladder Carcinoma: A Marker for Disease Progression,”
J Natl Cancer Inst, 1993; 85(1):53-59.
- Fitzgibbons PL, Page DL, Weaver D. et
al. “Prognostic Factors in Breast Cancer. College of
American Pathologists Consensus Statement 1999,” Arch
Pathol Lab Med, 2000; 124(7):966-978
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