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Afp4® Screening – Quadruple Marker Test (AFP, hCG, uE3, Inhibin A)

Afp4 screens for fetal Down syndrome, trisomy 18 and open neural tube defects between 15 weeks / 0 days and 21 weeks / 6 days (15.0-21.9 weeks). Optimal time is between 16 and 18 weeks. Four biochemical markers, alphafetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3) and dimeric Inhibin-A are analyzed in a maternal serum sample to provide risk assessments for Down syndrome, trisomy 18 and open neural tube defects in the second trimester.for fetal Down syndrome, trisomy 18 and open neural tube defects between 15 weeks / 0 days and 21 weeks / 6 days (15.0-21.9 weeks). Optimal time is between 16 and 18 weeks. Four biochemical markers, alphafetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3) and dimeric Inhibin-A are analyzed in a maternal serum sample to provide risk assessments for Down syndrome, trisomy 18 and open neural tube defects in the second trimester.

CPT Codes:

82105(1), 84702(1), 86336(1), 82677(1)


Specimen Requirements:

Please Note: Ultrasound BPD (biparietal diameter) dating of pregnancy is preferred for optimal accuracy of risk calculations.

  1. Serum:
    • AFP tube.
    • 2-3 ml (unhemolyzed).
  2. Whole Blood:
    • Serum separator tube (SST) or red-top tube.
    • 7 ml in SST or 10 ml in red-top tube; allow to clot; centrifuge (15 minutes at 1,000 g) to prevent hemolysis.

Turnaround Time:

2-3 days


Client Services: Reproductive Genetics   800-848-4436

Specimen Services/Pickup:  877-246-1226

Reproductive Genetics Client Services

Tel: 800-848-4436