Our global life sciences company brings diagnostic testing & drug development together.

SeroNeg RAdx3 Profile (RDL)

CPT: 83516(x2); 83520
83516(x2); 83520
Updated on 10/13/2021
Print Share

Expected Turnaround Time

7 - 10 days

7 - 10 days

7 - 10 days

7 - 10 days

7 - 10 days

Related Documents

For more information, please view the literature below.

Rheumatoid Arthritis: Novel Serologic Markers White Paper

For more information, please view the literature below.

Rheumatoid Arthritis: Novel Serologic Markers White Paper

Specimen Requirements




3 mL

Minimum Volume

3 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Storage Instructions


Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details


SeroNeg RAdx3 is a diagnostic and prognostic panel for Rheumatoid Arthritis designed to complement traditional RF and Anti-CCP testing.

This profile, consisting of 14-3-3 eta protein, Anti -CEP-1 Ab and Anti-Sa Ab, enhances the diagnosis of established or early RA (in individuals seronegative for RF and Anti-CCP Ab) and also helps predict disease severity.

Decrease in 14-3-3eta and/or Anti-Sa Ab with treatment is associated with less radiographic progression. The presence of Anti-CEP1 and Anti-CCP Antibodies suggests the imminent progression of pre-clinical RA into clinical RA.


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Enzyme-linked Immunosorbent Assay (ELISA)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520209 SeroNeg RAdx3 Profile (RDL) REQUEST 520206 14.3.3 ETA, Rheum. Arthritis ng/mL 75880-5
520209 SeroNeg RAdx3 Profile (RDL) REQUEST 520207 Anti-CEP-1 Ab, IgG (RDL) Units 96561-6
520209 SeroNeg RAdx3 Profile (RDL) REQUEST 520208 Anti-Sa Ab, IgG (RDL) Units 54022-9

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at