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Inflammatory Bowel Disease (IBD) Profile with Anti-Pancreatic Antibodies (RDL)

CPT: 83516(x2); 86255(x2)
83520(x2); 86255(x2)
83516(x2); 86255(x2)
Updated on 10/13/2021
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Test Includes

ANCA by Indirect Fluorescent Antibody (IFA), ASCA, IgG, ASCA, IgA, Anti-Pancreatic Ab (IFA), ANA by IFA (only if atypical p-ANCA)


Expected Turnaround Time

10 - 12 days

10 - 12 days

10 - 12 days

10 - 12 days

10 - 12 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

4 mL


Minimum Volume

3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.


Storage Instructions

Refrigerate.


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types


Test Details


Use

Crohn's Disease (CD) and Ulcerative Colitis (UC) are two distinct clinical subtypes of IBD. ASCA is more sensitive and specific for CD, and atypical P-ANCA is more sensitive and specific for UC. Anti-Pancreatic Antibodies are highly specific for CD.

The combination of Atypical p-ANCA positive, ASCA negative and Anti-Pancreatic Ab negative is highly specific for ulcerative colitis.

The combination of Atypical p-ANCA negative, ASCA positive and Anti-Pancreatic Ab positive is highly specific for Crohn's disease.


Limitations

The diagnosis of IBD/CD/UC is made by a physician and is based on clinical, endoscopic, histological, radiological, and biochemical features.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Indirect fluorescent antibody (IFA), Enzyme Immunoassay (EIA)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520190 IBD Profile (RDL) 520120 Anti-Pancreatic Ab by IFA RDL 5265-4
520190 IBD Profile (RDL) 520184 ASCA, IgG Units 63333-9
520190 IBD Profile (RDL) 520186 ASCA, IgA Units 63331-3
520190 IBD Profile (RDL) 520255 ANCA by IFA (RDL) 35279-9
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520187 C-ANCA (IFA-ETOH) 14277-8
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520189 P-ANCA (IFA-ETOH) 14278-6
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520191 P-ANCA (IFA-Formalin) 17357-5
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520240 Centriole Pattern 54151-6
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520247 Positive ANCA Reflex 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex 2 520256 ANA Titer and Pattern 520241 Note: 77202-0

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf