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RAdx5 Profile (RDL)

CPT: 83516(x2); 83520; 86200; 86431
83520(x3); 86200; 86431
83516(x2); 83520; 86200; 86431
Updated on 10/13/2021
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Test Includes

RF by Turb; Anti-CCP (Cyclic Citrullinated Peptide) Ab, IgG & IgA; 14.3.3 eta; Anti-CEP1 Ab, IgG; Anti-Sa Ab, IgG

Expected Turnaround Time

14 - 21 days

Related Documents

For more information, please view the literature below.

Rheumatoid Arthritis: Novel Serologic Markers White Paper

For more information, please view the literature below.

Rheumatoid Arthritis: Novel Serologic Markers White Paper

Specimen Requirements




3 mL

Minimum Volume

3 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping

Storage Instructions


Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic, icteric, non-serum specimen types

Test Details


The RAdx5™ is a novel comprehensive diagnostic and prognostic panel for rheumatoid arthritis available exclusively at RDL. It combines 3 novel markers (14-3-3n, anti-CEP-1 and anti-Sa) with 2 traditional markers (anti-CCP and RF-IgM) to not only enhance the diagnosis of RA in early or established disease, but also to help predict disease severity. If 14-3-3n and/or anti-Sa positivity is present, the disappearance or decrease of these antibodies with treatment is associated with less radiographic progression. In pre-clinical RA, positivity of anti-CEP-1 along with anti-CCP antibodies significantly raises the risk of imminently developing clinical RA.

References available upon request.


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Enzyme-linked immunosorbent assay (ELISA); Turbidimetry


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520091 RAdx5 Profile (RDL) 520226 Anti-CCP Ab, IgG & IgA (RDL) Units 57093-7
520091 RAdx5 Profile (RDL) 520093 Rheumatoid Factor by Turb RDL IU/mL 11572-5
520091 RAdx5 Profile (RDL) 520262 14.3.3 ETA, Rheum. Arthritis ng/mL 75880-5
520091 RAdx5 Profile (RDL) 520263 Anti-CEP-1 Ab, IgG (RDL) Units 96561-6
520091 RAdx5 Profile (RDL) 520264 Anti-Sa Ab, IgG (RDL) Units 54022-9

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