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MyoMarker® 3 Profile (RDL)

CPT: 83516(x8); 83520; 86235(x7)


  • Myomarker 3
  • Myositis
  • Myositis Panel 3

Test Includes

Anti-PM/Sci-100 Ab; Anti-MDA5 Ab (CADM-140); Anti-NXP-2 Ab; Anti-TIF-1 gamma Ab; Anti-SRP Ab; Anti-U3 RNP (Fibrillarin Ab); Anti-U2 RNP Ab; Anti-Mi-2 Ab; Anti-PL-7 Ab; Anti-PL-12 Ab; Anti-EJ Ab; Anti-OJ Ab; Anti-Ku Ab; Anti-Jo-1 Ab; Anti-U1 RNP Ab; Anti-SS-A 52kD Ab, IgG

Expected Turnaround Time

16 days

Related Documents

Specimen Requirements




3 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Refrigerate or freeze.

Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details


The idiopathic inflammatory myopathies (IIM) are a hetergeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical utilities that fall into two main groups. One group of autoantibodies are found in patients with myositis and are known as Myositis Specific Autoantibodies (MSA). The MSAs are highly specific for patients with polymyositis (PM) dermatmyositis (DM), anti-synthetase syndrome and necrotizing myositis. The second group of autoantibodies are considered Myositis Associated Autoantibodies (MAA). These appear in myositis overlap syndrome and in other connective tissue diseases, which correlate with certain clinical and/or pathophysiological conditions.


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Enzyme-linked immunosorbent assay (ELISA); RIPA Gel Radiography

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