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Autoimmune Epilepsy Profile, Serum

CPT: 86255(x3); 86341
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Specimen Requirements


Specimen

Serum


Volume

2 mL


Minimum Volume

1 mL (Note: this volume does not allow for repeat testing.)


Container

Serum from a red-top tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Gross hemolysis; grossly lipemic; gross icetrus


Test Details


Use

Evaluation of Autoimmune Epilepsy Antibody with Reflex to Titer


Limitations

Negative results do not exclude autoimmune encephalopathy or cancer.

This test does not detect Ma1 or Ma2 antibodies (alias MaTa), which are sometimes associated with brainstem and limbic epilepsy in the context of testicular germ cell neoplasms.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Cell-based Immunofluorescence (IFA) and ELISA


Additional Information

The Epilepsy Antibody Panel provides an evaluation of possible autoantibodies in patients with suspected autoimmune Epilepsy, and optimizes the likelihood of detecting neuronal specific autoantibodies, whether present singly or occurring as multiple autoantibodies.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
505400 Autoimmune Epilepsy Ab 505401 NMDA Cell-based IFA pending
505400 Autoimmune Epilepsy Ab 505314 LGI-1 Cell-based IFA pending
505400 Autoimmune Epilepsy Ab 505429 CASPR2 Cell-based IFA pending
505400 Autoimmune Epilepsy Ab 143010 GAD-65 U/mL 56540-8
Reflex Table for NMDA Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505402 NMDA Antibody, Titer, Serum 505402 NMDA Antibody, Titer, Serum pending
Reflex Table for LGI-1 Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505315 LGI-1 Antibody, Titer, Serum 505315 LGI-1 Antibody, Titer, Serum pending
Reflex Table for CASPR2 Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505411 CASPR2 Antibody, Titer, Serum 505411 CASPR2 Antibody, Titer, Serum pending

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf