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COMT Genetic Test

CPT: 81479
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  • COMT Genotype

Expected Turnaround Time

8 - 21 days

Related Documents

For more infomation, please view the literature below.

Informed Consent for COMT Genetic Testing

Specimen Requirements


Whole blood or LabCorp buccal swab kit (buccal swab collection kit)


3 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing).


Lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab from kit

Storage Instructions

Room temperature

Stability Requirements



Room temperature

28 days


28 days

Causes for Rejection

Frozen sample, hemolysis; incorrect collection kit

Test Details


COMT alleles have been associated with disease risk or drug responsiveness (e.g. early vs. late Parkinson's disease, schizophrenia, chronic pain conditions). The COMT genotype plays a role in cognition and behavioral modification (e.g. smoking cessation, modafinil responsiveness in sleep deprivation and addiction treatment), and potentially influences estrogen-related conditions (e.g. breast cancer risk when taking hormone replacement therapy, recurrent preeclampsia).


Only the 6 SNPs in question are tested; polymorphisms or some sequence variants might affect efficiency of the PCR or mini-sequencing assays. Haplotype phases are inferred based on our validation studies. Donor DNA from transplants and recent transfusions can lead to inaccurate results.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Polymerase chain reaction (PCR) and multiplex mini-sequencing


Bodenmann S & Landolt HP. Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 2010 Aug;33(8):1027-1035.20815183
Corvol JC, Bonnet C, Charbonnier-Beaupel F, et al. The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. Ann Neurol. 2011 Jan;69(1):111-118.21280081
David SP, Johnstone EC, Churchman M, Aveyard P, Murphy MF, Munafò MR. Pharmacogenetics of smoking cessation in general practice: results from the patch II and patch in practice trials. Nicotine Tob Res. 2011 Mar;13(3):157-167.21330274
Diatchenko L, Slade GD, Nackley AG, et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2005 Jan 1;14(1):135-143.15537663
Li Y, Yang X, van Breemen RB, Bolton JL. Characterization of two new variants of human catechol O-methyltransferase in vitro. Cancer Letters. 2005 Dec 8;230(1):81-89.16253764
Meloto CB, Segall SK, Smith S, et al. COMT gene locus: new functional variants. Pain. 2015 Oct;156(10):2072-2083.26207649
Nackley AG, Shabalina SA, Tchivileva IE, et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science. 2006 Dec 22;314(5807):1930-1933.17185601


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504576 COMT Genetic Test 504990 rs4680 N/A
504576 COMT Genetic Test 504991 rs6267 N/A
504576 COMT Genetic Test 504992 rs165774 N/A
504576 COMT Genetic Test 504993 rs6269 N/A
504576 COMT Genetic Test 504994 rs4633 N/A
504576 COMT Genetic Test 504995 rs4818 N/A
504576 COMT Genetic Test 504580 COMT Genetic Test Information 51968-6
504576 COMT Genetic Test 504581 Comments 77202-0
504576 COMT Genetic Test 000000 Esoterix Informed Consent Req N/A

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CPT Statement/Profile Statement

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